Evidence map›Paper›PMID 33585449›Full record

ArticleFrontiers in cell and developmental biology2020

Highly Sensitive and Multiplexed Protein Imaging With Cleavable Fluorescent Tyramide Reveals Human Neuronal Heterogeneity.

Renjie Liao, Manas Mondal, Christopher D Nazaroff, Diego Mastroeni, Paul D Coleman, Joshua Labaer, Jia Guo

Abstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Emerging technologies in the spatial proteomics landscape.Analytical and bioanalytical chemistry · 2026
    Review
  2. Review
  3. Comparative Evaluation of Antibody-Oligonucleotide Conjugation Strategies for Multiplexed Imaging Applications.Laboratory investigation; a journal of technical methods and pathology · 2026
    Article
  4. Article
  5. Article
  6. Single-cell spatial proteomics.Histology and histopathology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Recent methodological advances towards single-cell proteomics.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023
    Review
  11. Article
  12. Article
  13. Multiplexed Single-Cell in Situ Protein Profiling.ACS measurement science au · 2022
    Review
  14. Article
  15. The Intriguing Landscape of Single-Cell Protein Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Renjie LiaoBiodesign Institute & School of Molecular Sciences, Arizona State University, Tempe, AZ, United States.
Manas MondalBiodesign Institute & School of Molecular Sciences, Arizona State University, Tempe, AZ, United States.
Christopher D NazaroffBiodesign Institute & School of Molecular Sciences, Arizona State University, Tempe, AZ, United States.
Diego MastroeniArizona State University-Banner Neurodegenerative Disease Research Center, Biodesign Institute and School of Life Sciences, Arizona State University, Tempe, AZ, United States.
Paul D ColemanArizona State University-Banner Neurodegenerative Disease Research Center, Biodesign Institute and School of Life Sciences, Arizona State University, Tempe, AZ, United States.
Joshua LabaerBiodesign Institute & School of Molecular Sciences, Arizona State University, Tempe, AZ, United States.
Jia GuoBiodesign Institute & School of Molecular Sciences, Arizona State University, Tempe, AZ, United States.

Funding

Novel in situ proteomics methods to classify cell types in Alzheimer’s brains - Administrative SupplementR01GM127633 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI GUO, JIA · 2018 to 2022
$1.8M
Imaging Functionally Distinct Eosinophil Subtypes Within Tissue Biopsies Using Gene Expression Profiling and an In Situ Hybridization Approach based on a Concurrent Multiple RNA Targeting StrategyR21AI132840 · NIAID · MAYO CLINIC ARIZONA · PI JACOBSEN, ELIZABETH A · 2018 to 2019
$463k
NIAID NIH HHS R21 AI132840NIGMS NIH HHS R01 GM127633
6 · The paper itself

Abstract

The ability to comprehensively profile proteins in intact tissues

Indexed as

hippocampusimmunofluorescenceimmunohistochemistrysingle-cellspatial proteomics

Identifiers

PMID33585449
PMCPMC7874177

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.