Evidence map›Paper›PMID 33585361›Full record

ReviewFrontiers in pediatrics2020

Nutritional Factors in the Prevention of Atopic Dermatitis in Children.

Thulja Trikamjee, Pasquale Comberiati, Enza D'Auria, Diego Peroni, Gian Vincenzo Zuccotti

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06035835 (Probiotics and Breastmilk Are Associated With a Decreased Risk of Atopic Dermatitis in Very Low Birth Weight Premature Infants), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06035835 completednot on this map

Probiotics and Breastmilk Are Associated With a Decreased Risk of Atopic Dermatitis in Very Low Birth Weight Premature Infants

TypeobservationalSponsorJosé Uberos FernándezRan2009 to 2022Enrolled437ConditionsAtopic DermatitisArmsLacticaseibacillus rhamnosus, Lactobacillus acidophilus + Bifidobacterium bifidum
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
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  6. Targeting Pollutants in the Treatment and Prevention of Atopic Dermatitis.Immunology and allergy clinics of North America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Thulja TrikamjeeAllergy and Immunology Unit, University of Cape Town Lung Institute, Cape Town, South Africa.
Pasquale ComberiatiDepartment of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy.
Enza D'AuriaDepartment of Health Sciences, University of Milan, Milan, Italy.
Diego PeroniDepartment of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy.
Gian Vincenzo ZuccottiDepartment of Health Sciences, University of Milan, Milan, Italy.
University of Milan · ITUniversity of Pisa · ITSouth African Tuberculosis Vaccine Initiative · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atopic dermatitis is one of the most frequent chronic skin diseases worldwide and often develops within the first few years of life. Recent advancements in our knowledge of its pathophysiology have brought to light the role of genetic predisposition and environmental triggers. With the increasing prevalence of allergic diseases, there is a strong need for a better understanding of the various modifiable eliciting factors of such conditions. The concomitant rise in food allergy and insights into the skin barrier function has highlighted the role of nutrition and diet in the prevention and modification of allergic disorders. Furthermore, the identification of the skin as an important route of sensitization, and the risk of progression to asthma later in life, stress the significance of optimizing our management of skin inflammation in the prevention of allergies. Many nutritional factors, including the type of maternal diet during pregnancy, the duration of breastfeeding, the epicutaneous exposure of allergenic food proteins in the first few years of life, the timing of the introduction of complementary foods, the supplementation of vitamins and probiotics/prebiotics during prenatal and early life, have been assessed as potential targets for the prevention of atopy and eczema. Here, we review the latest data addressing prenatal and perinatal nutritional and dietary interventions in the primary prevention of atopic dermatitis. Also, we define knowledge gaps and targets for future research in the prevention of atopic dermatitis.

Indexed as

atopic dermatitisbreastfeedingchildrencomplementary foodsomega-3 long-chain polyunsaturated fatty acidspreventionprobioticsvitamin D

Identifiers

PMID33585361
PMCPMC7874114
OpenAlexW3118624615

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.