Evidence map›Paper›PMID 33585283›Full record

ArticleFrontiers in cellular and infection microbiology2020

Tonsil Mycobiome in PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis) Syndrome: A Case-Control Study.

Mysore V Tejesvi, Terhi Tapiainen, Petri Vänni, Matti Uhari, Marko Suokas, Ulla Lantto, Petri Koivunen, Marjo Renko

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mysore V TejesviEcology and Genetics, Faculty of Science, University of Oulu, Oulu, Finland.
Terhi TapiainenBiocenter Oulu, University of Oulu, Oulu, Finland.
Petri VänniGenobiomics LLC, Oulu, Finland.
Matti UhariBiocenter Oulu, University of Oulu, Oulu, Finland.
Marko SuokasEcology and Genetics, Faculty of Science, University of Oulu, Oulu, Finland.
Ulla LanttoPEDEGO Research Unit, University of Oulu, Oulu, Finland.
Petri KoivunenPEDEGO Research Unit, University of Oulu, Oulu, Finland.
Marjo RenkoPEDEGO Research Unit, University of Oulu, Oulu, Finland.
University of Oulu · FIOulu University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA) is the most common periodic fever syndrome in children with unknown etiology, effectively treated with tonsillectomy. Earlier we have shown that tonsil microbiome is different in patients with PFAPA as compared to that in controls. Recently, fungal microbiome, mycobiome, has been linked to the pathogenesis of inflammatory diseases. We now investigated the role of mycobiome of tonsils in PFAPA. Random forest classification, a machine learning approach, was used for the analysis of mycobiome data. We examined tonsils from 30 children with PFAPA and 22 control children undergoing tonsillectomy for non-infectious reasons. We identified 103 amplicon sequence variants, mainly from two fungal phyla, Ascomycota and Basidiomycota. The mean relative abundance of

Indexed as

LymphadenitisMycobiomePharyngitisStomatitis, AphthousCase-Control StudiesChildHumansPalatine Tonsilmachine leariningmycobiomenext generation sequencingPFAPAtonsil

Identifiers

PMID33585283
PMCPMC7873641
OpenAlexW3124987487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.