Evidence map›Paper›PMID 33585279›Full record

ReviewFrontiers in cellular and infection microbiology2020

Roles of Gut Microbiota in the Regulation of Hippocampal Plasticity, Inflammation, and Hippocampus-Dependent Behaviors.

Wen Tang, Zhaoyou Meng, Ning Li, Yiyan Liu, Li Li, Dongfeng Chen, Yang Yang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
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  3. The microbiota-gut- hippocampus axis.Frontiers in neuroscience · 2022
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  16. Gut microbiome and host TOR pathway interact to regulate predator-induced aversive memory inProceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Wen TangDepartment of Gastroenterology, Daping Hospital, Army Medical University, Chongqing, China.
Zhaoyou MengDepartment of Neurology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Ning LiDepartment of Gastroenterology, Daping Hospital, Army Medical University, Chongqing, China.
Yiyan LiuCollege of Basic Medicine, Army Medical University, Chongqing, China.
Li LiDepartment of Gastroenterology, The First People's Hospital in Chongqing Liangjiang New Area, Chongqing, China.
Dongfeng ChenDepartment of Gastroenterology, Daping Hospital, Army Medical University, Chongqing, China.
Yang YangDepartment of Gastroenterology, Daping Hospital, Army Medical University, Chongqing, China.
Army Medical University · CNDaping Hospital · CNFirst People's Hospital of Chongqing · CNXinqiao Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study of the gut microbiota-brain axis has become an intriguing field, attracting attention from both gastroenterologists and neurobiologists. The hippocampus is the center of learning and memory, and plays a pivotal role in neurodegenerative diseases, such as Alzheimer's disease (AD). Previous studies using diet administration, antibiotics, probiotics, prebiotics, germ-free mice, and fecal analysis of normal and specific pathogen-free animals have shown that the structure and function of the hippocampus are affected by the gut microbiota. Furthermore, hippocampal pathologies in AD are positively correlated with changes in specific microbiota. Genomic and neurochemical analyses revealed significant alterations in genes and amino acids in the hippocampus of AD subjects following a remarkable shift in the gut microbiota. In a recent study, when young animals were transplanted with fecal microbiota derived from AD patients, the recipients showed significant impairment of cognitive behaviors, AD pathologies, and changes in neuronal plasticity and cytokines. Other studies have demonstrated the side effects of antibiotic administration along with the beneficial effects of probiotics, prebiotics, and specific diets on the composition of the gut microbiota and hippocampal functions, but these have been mostly preliminary with unclear mechanisms. Since some specific gut bacteria are positively or negatively correlated to the structure and function of the hippocampus, it is expected that specific gut bacteria administration and other microbiota-based interventions could be potentially applied to prevent or treat hippocampus-based memory impairment and neuropsychiatric disorders such as AD.

Indexed as

Alzheimer DiseaseGastrointestinal MicrobiomeProbioticsAnimalsHippocampusHumansInflammationMiceAlzheimer’s diseasegut microbiotahippocampusinflammationlearning and memorysenile plaque

Identifiers

PMID33585279
PMCPMC7873527
OpenAlexW3121452954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.