ArticleFrontiers in cellular and infection microbiology2020
Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project.
Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- From culture-based to 16S sequencing approaches: oral microbiota changes in aging, frailty, and oral hypofunction - a systematic review.BMC oral health · 2026Pooled it
- Detection of Oral Bacterial DNA in Abdominal Aortic Aneurysm and Its Microbial Associations.International journal of molecular sciences · 2026Article
- Association of anterior crossbite and open bite with the number of remaining teeth: A cross-sectional study from the Tohoku medical megabank cohort.Clinical oral investigations · 2026Article
- Comparative machine learning analysis of saliva and plaque microbiomes in Kuwaitis with type 1 diabetes.Frontiers in microbiology · 2026Article
- Microbial signatures of dental caries in the incarcerated elderly: a salivary microbiota study in a restricted environment.Journal of oral microbiology · 2026Article
- Ecological and Functional Landscape of the Oral Microbiome: A Multi-Site Analysis of Saliva, Dental Plaque and Tongue Coating.Microorganisms · 2025Article
- Characteristics of Subgingival Plaque Microbiome in Japanese Older Adults With Healthy Gingiva.Journal of clinical periodontology · 2025Article
- Enhancing Professional Periodontal Therapy with a Novel PMA-Zeolite Application: A Clinical Study on Periodontal Outcomes and Microbiological Changes.Journal of functional biomaterials · 2025Article
- Distribution and Characteristics of Oral Pathogens According to Blood Glucose Levels in South Korean Health Examinees.International journal of molecular sciences · 2025Article
- Saliva assay: a call for methodological standardization.Journal of periodontal & implant science · 2025Review
- The oral microbiome in aging: a window into health and longevity.Journal of oral microbiology · 2025Review
- Nepali oral microbiomes reflect a gradient of lifestyles from traditional to industrialized.Microbiome · 2024Article
- Comparative analysis of microbiome in coronal and root caries.BMC oral health · 2024Article
- Sequential Sampling of the Gastrointestinal Tract to Characterize the Entire Digestive Microbiome in Japanese Subjects.Microorganisms · 2024Article
- Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals.Journal of biochemistry · 2024Article
- Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study.BMC public health · 2024Article
- Oral Function and the Oral Microbiome in the Elderly in the Kyotango Area.Dentistry journal · 2024Article
- jMorp: Japanese Multi-Omics Reference Panel update report 2023.Nucleic acids research · 2024Article
- Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background.JMA journal · 2023Review
- The Oral Microbiome as Mediator between Oral Hygiene and Its Impact on Nasopharyngeal Carcinoma.Microorganisms · 2023Article
Corrections and comments
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Authors and funding
19 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A baseline oral microbiome study of the Tohoku Medical Megabank Organization (TMM) was planned to characterize the profile of the oral microbiome in the Japanese population. The study also aimed to clarify risk factors for multifactorial diseases by integrated analysis of the oral microbiome and host genome/omics information. From 2013 to 2016, we collected three types of oral biospecimens, saliva, supragingival plaque, and tongue swab, from a total of 25,101 participants who had a dental examination in TMM. In this study, we used two independent cohorts; the Community-Based Cohort and Birth and Three-Generation Cohort as discovery and validation cohorts, respectively, and we selected participants examined by a single dentist. We found through the 16S ribosomal RNA gene sequencing analysis of 834 participants of the Community-Based Cohort Study that there are differences in the microbial composition and community structure between saliva and plaque. The species diversities in both saliva and plaque were increased in correlation with the severity of periodontal disease. These results were nicely reproduced in the analysis of 455 participants of the Birth and Three-Generation Cohort Study. In addition, strong positive and negative associations of microbial taxa in both plaque and saliva with periodontitis-associated biofilm formation were detected by co-occurrence network analysis. The classes
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