Evidence map›Paper›PMID 33585246›Full record

ArticleFrontiers in oncology2020

Increased Risk of Cardiovascular Death in Breast Cancer Patients Without Chemotherapy or (and) Radiotherapy: A Large Population-Based Study.

Tianwang Guan, Hanbin Zhang, Jinming Yang, Wenrui Lin, Kenie Wang, Miao Su, Weien Peng, Yemin Li, Yanxian Lai, Cheng Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 25 citations in OpenAlex.

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  7. NETs: an extracellular DNA network structure with implication for cardiovascular disease and cancer.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Review
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  16. Emerging mitochondrial signaling mechanisms in cardio-oncology: beyond oxidative stress.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Tianwang GuanDepartment of Cardiology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Hanbin ZhangDepartment of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Jinming YangDepartment of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Wenrui LinDepartment of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Kenie WangThe First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Miao SuDepartment of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Weien PengDepartment of Clinical Medicine, Clinical Medical School, Guangzhou Medical University, Guangzhou, China.
Yemin LiDepartment of Clinical Medicine, Clinical Medical School, Guangzhou Medical University, Guangzhou, China.
Yanxian LaiDepartment of Cardiology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Cheng LiuDepartment of Cardiology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Guangzhou Medical University · CNGuangzhou First People's Hospital · CNSouth China University of Technology · CNTianjin Medical University Cancer Institute and Hospital · CNZhujiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiovascular death (CVD) in breast cancer patients without chemotherapy (CT) or (and) radiotherapy (RT) has not been studied yet. This study evaluates the correlation between breast cancer and CVD risk independent of chemotherapy or (and) radiotherapy.

methodsData of female breast cancer patients without receiving CT or RT were retrieved from the Surveillance, Epidemiology, and End Result (SEER) database (2004-2015). Data were divided into two cohorts: tumor resection cohort and no resection cohort. The CVD risk in patients was expressed as standardized mortality ratios (SMRs). A 1:1 propensity score matching (PSM) was applied to balance inter-group bias, and competing risk regressions were utilized to evaluate the impact of tumor resection on CVD.

resultsThe CVD risk was significantly higher (SMR = 2.196, 95% CI: 2.148-2.245,

conclusionsFemale breast cancer patients are at higher risk of CVD despite unexposure to cardio-toxic CT or RT. However, female breast cancer patients subjected to tumor resection have decreased CVD risk. These results indicated that monitoring female breast cancer patients not receiving RT or CT might serve as a preventative measure against CVD.

Indexed as

breast cancercardio-oncologycardiovascular deathchemotherapyradiotherapy

Identifiers

PMID33585246
PMCPMC7876382
OpenAlexW3127457627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.