Evidence map›Paper›PMID 33585175›Full record

ReviewWorld journal of virology2021

Emerging therapeutics in the management of COVID-19.

Asim Kichloo, Michael Albosta, Akshay Kumar, Michael Aljadah, Mohamed Mohamed, Zain El-Amir, Farah Wani, Shakeel Jamal, Jagmeet Singh, Akif Kichloo

Abstract readReview
In one paragraph

Review in World journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. [Venovenous extracorporeal membrane oxygenation for COVID-19].Zeitschrift fur Herz-, Thorax- und Gefasschirurgie · 2022
    Review
  4. [Impact of the COVID-19 pandemic on cardiac surgery].Zeitschrift fur Herz-, Thorax- und Gefasschirurgie · 2022
    Review
  5. Immunological map in COVID-19.Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Asim KichlooDepartment of Internal Medicine, Samaritan Medical Center, Watertown, NY 13601, United States.
Michael AlbostaDepartment of Internal Medicine, Central Michigan University, Saginaw, MI 48602, United States. albos1ms@cmich.edu.
Akshay KumarDepartment of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA 15260, United States.
Michael AljadahDeparment of Internal Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, United States.
Mohamed MohamedDepartment of Internal Medicine, Central Michigan University, Saginaw, MI 48602, United States.
Zain El-AmirDepartment of Internal Medicine, Central Michigan University, Saginaw, MI 48602, United States.
Farah WaniDepartment of Family Medicine, Samaritan Medical Center, Watertown, NY 13601, United States.
Shakeel JamalDepartment of Internal Medicine, Central Michigan University, Saginaw, MI 48602, United States.
Jagmeet SinghDepartment of Transplant Nephrology, Geisinger Commonwealth School of Medicine, Sayre, PA 18510, United States.
Akif KichlooDepartment of Anesthesiology and Critical Care, Saraswathi Institue of Medical Sciences, Uttar Pradesh 245304, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019, COVID-19) pandemic has placed a tremendous burden on healthcare systems globally. Therapeutics for treatment of the virus are extremely inconsistent due to the lack of time evaluating drug efficacy in clinical trials. Currently, there is a deficiency of published literature that comprehensively discusses all therapeutics being considered for the treatment of COVID-19. A review of the literature was performed for articles related to therapeutics and clinical trials in the context of the current COVID-19 pandemic. We used PubMed, Google Scholar, and Clinicaltrials.gov to search for articles relative to the topic of interest. We used the following keywords: "COVID-19", "therapeutics", "clinical trials", "treatment", "FDA", "ICU", "mortality", and "management". In addition, searches through the references of retrieved articles was also performed. In this paper, we have elaborated on the therapeutic strategies that have been hypothesized or trialed to-date, the mechanism of action of each therapeutic, the clinical trials finished or in-process that support the use of each therapeutic, and the adverse effects associated with each therapeutic. Currently, there is no treatment that has been proven to provide significant benefit in reducing morbidity and mortality. There are many clinical trials for numerous different therapeutic agents currently underway. By looking back and measuring successful strategies from previous pandemics in addition to carrying out ongoing research, we provide ourselves with the greatest opportunity to find treatments that are beneficial.

Indexed as

COVID-19Infectious diseasePharmacologySARS-CoV-2TherapeuticsVirology

Identifiers

PMID33585175
PMCPMC7852573

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.