Evidence map›Paper›PMID 33585170›Full record

ArticleJournal of herbal medicine2021

Impact of acute, oral ingestion of hypoxoside from African potato on hepatic and renal function tests in HIV infected patients on combination antiretroviral therapy.

Celia M J Matyanga, Gene D Morse, Mazuru Gundidza, Billy Ndawana, Andrew Reid, Inam Chitsike, Charles F B Nhachi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of herbal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Celia M J MatyangaDepartment of Clinical Pharmacology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Gene D MorseCenter for Integrated Global Biomedical Sciences; School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, United States.
Mazuru GundidzaDepartment of Pharmaceutical Technology, School of Industrial Sciences and Technology, Harare Institute of Technology, Belvedere, Harare, Zimbabwe.
Billy NdawanaHarare Municipality Medical Aid Laboratories (HMMI), 133 Nelson Mandela, Corner 6th Street, Harare, Zimbabwe.
Andrew ReidDepartment of Clinical Pharmacology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Inam ChitsikeDepartment of Pediatrics, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Charles F B NhachiDepartment of Clinical Pharmacology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
University of Zimbabwe · ZWHarare Institute of Technology · ZWUniversity at Buffalo, State University of New York · US

Funding

HIV Research Training ProgramD43TW010313 · FIC · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Charles Enos Chiedza Maponga, Gene D. Morse · 2016 to 2026
$3.2M
Antiretroviral Pharmacology Training in Resource Poor CountriesD43TW007991 · FIC · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MORSE, GENE D. · 2009 to 2015
$1.6M
FIC NIH HHS D43 TW007991FIC NIH HHS D43 TW010313
6 · The paper itself

Abstract

objectivesAfrican potato (

methodsThis was an open-label, two-period, fixed-sequence, pre-post test study, pilot design. Ethical approval was obtained from Medical Research Council of Zimbabwe (MRCZ A/2045) and Medicines Control Authority of Zimbabwe (MCAZ CT134/2016). Blood samples were collected before and after administration of African potato tablets. Tablets were administered orally once daily at 15mg/ kg hypoxoside for 10 days. Hepatic function tests (ALT, AST, ALP, GGT, albumin, total/ direct bilirubin); renal function tests (eGFR, blood urea nitrogen, creatinine), serum electrolytes (sodium, potassium, chloride) were assayed. STATA was used for statistical analysis.

resultsTwenty-six participants were enrolled (85% female). Median age (range) was 43 (28-52) years. Most had overweight Body Mass Index (46%) and were married (54%). No statistical difference was noted during hypoxoside for AST/ ALT/ ALP/ GGT/ albumin/ bilirubin. There were no changes in creatinine/ eGFR/ electrolytes. A mean significant increase in total protein (p=0.04) and decrease in blood urea nitrogen (p=0.04) were noted.

conclusionShort-term exposure to hypoxoside from African potato appeared safe and was not associated with clinically significant changes in hepatic, renal function tests/electrolytes. There is further need to evaluate extent of systemic exposure during long-term use in a larger population.

Indexed as

African potatoHIVhypoxis hemerocallideahypoxosidekidneylivertraditional medicine

Identifiers

PMID33585170
PMCPMC7877801
OpenAlexW3118692730

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.