ArticleCurrent treatment options in allergy2020
Filaggrin gene mutations with special reference to atopic dermatitis.
Article in Current treatment options in allergy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Prenatal maternal antibiotic use increases the risk of childhood eczema: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Cosmetogenomics unveiled: a systematic review of AI, genomics, and the future of personalized skincare.Frontiers in artificial intelligence · 2025Pooled it
- From Skin to Solution: Exploring Epicutaneous Immunotherapy for Peanut Allergy-A Systematic Review and Meta-Analysis.Clinical reviews in allergy & immunology · 2024Pooled it
- Pooled it
- Filaggrin Mutation Status and Prevention of Atopic Dermatitis with Maternal Probiotic Supplementation.Acta dermato-venereologica · 2024Trial
- Early Risk Assessment and Recognition of Allergies in Children: Rationale, Methodology, and Proposed Algorithms.Allergy · 2026Review
- Review
- Genetic profiling of patients with atopic dermatitis reveals immune and skin barrier variants associated with generalized eczema and optimal response to Dupilumab therapy.Frontiers in immunology · 2026Article
- Study on the Mechanism of Anti-Atopic Dermatitis by Herba Siegesbeckiae Based on Metabolomics.Combinatorial chemistry & high throughput screening · 2026Article
- Distinct microbial and functional alterations across skin sites and disease severity in pediatric atopic dermatitis: a prospective study.Frontiers in medicine · 2026Article
- Incidence and Remission of Atopic Dermatitis in a German Birth Cohort.JAMA network open · 2025Observational
- The Mechanisms of Immunoglobulin E Sensitizations in Atopic Dermatitis.Immunology and allergy clinics of North America · 2025Review
- Utilization of Dietary Supplements in People with the Atopic Triad in Korea: A Cross-Sectional Study Using KNHANES (2018-2021).Medicina (Kaunas, Lithuania) · 2025Article
- Advancements in pharmacological interventions for atopic dermatitis current strategies and future directions.Inflammopharmacology · 2025Review
- The novel house dust mite allergen Der p 39 exacerbates atopic dermatitis-like inflammation in mice by inducing skin barrier dysfunction.The World Allergy Organization journal · 2025Article
- Lifestyle Factors in the Clinical Manifestation and Management of Atopic Dermatitis.Archives of internal medicine research · 2025Article
- Skin Barrier Repair and Nursing Care in Patients with Atopic Dermatitis: A Narrative Review.International journal of general medicine · 2025Review
- A multi-strain human skin microbiome model provides a testbed for disease modeling.Frontiers in microbiomes · 2025Article
- Rare Filaggrin Variants Are Associated with Pustular Skin Diseases in Asians.International journal of molecular sciences · 2024Article
- Filaggrin loss-of-function variants are associated with atopic dermatitis phenotypes in a diverse, early-life prospective cohort.JCI insight · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewMutations in the Filaggrin gene can cause absent or reduced filaggrin protein, leading to impaired keratinization and skin barrier defect, which produce characteristic phenotypes. In this short review, we report current evidence on the topic with special reference to atopic dermatitis, suggest future directions, and discuss therapeutic implications. RECENT
findingsNumerous candidate gene association studies, genome-wide association studies, studies on copy number variations and most recently, sequencing studies, have confirmed the robust association of mutations in the Filaggrin gene with atopic dermatitis, and have also linked these mutations with several other disorders. SUMMARY: Filaggrin gene defects remain the strongest identified genetic risk factors for atopic dermatitis. Taken in conjunction with other genes found to be associated with this condition, genetic screening and identification of individuals at risk for atopic dermatitis could lead to personalized therapy. Manipulation of genetic regulatory elements to increase the amount of filaggrin protein in deficient individuals is an attractive treatment option for the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.