ArticleCurrent addiction reports2020
The ups and downs of relating nondrug reward activation to substance use risk in adolescents.
Article in Current addiction reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review.Frontiers in human neuroscience · 2022Pooled it
- Striatal Prediction Error Tracking Moderates the Influence of Social Exposure on Adolescent Substance Use Curiosity.Human brain mapping · 2026Article
- Blunted reward-related striatal activity and behavioral disinhibition as a pathway to adolescent cannabis and e-cigarette use.Frontiers in adolescent medicine · 2026Article
- Unintended bias in the pursuit of collinearity solutions in fMRI analysis.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Adolescents' neural responses to their parents' emotions: associations with emotion regulation, internalizing symptoms, and substance use.Social cognitive and affective neuroscience · 2024Article
- The path from mood symptoms to substance use: A longitudinal examination in individuals with and at risk for bipolar spectrum disorders.Journal of affective disorders · 2024Article
- A multi-sample evaluation of the measurement structure and function of the modified monetary incentive delay task in adolescents.Developmental cognitive neuroscience · 2024Article
- Developmental Changes in Habenular and Striatal Social Reinforcement Responsivity Across Adolescence Linked With Substance Use.Biological psychiatry · 2023Article
- Sensitization-based risk for substance abuse in vulnerable individuals with ADHD: Review and re-examination of evidence.Neuroscience and biobehavioral reviews · 2022Review
- People with tobacco use disorder exhibit more prefrontal activity during preparatory control but reduced anterior cingulate activity during reactive control.Addiction biology · 2022Article
- Adolescent novelty seeking is associated with greater ventral striatal and prefrontal brain response during evaluation of risk and reward.Cognitive, affective & behavioral neuroscience · 2022Article
- Preliminary Evidence That Circadian Alignment Predicts Neural Response to Monetary Reward in Late Adolescent Drinkers.Frontiers in neuroscience · 2022Article
- Altered effective connectivity of the reward network during an incentive-processing task in adults with alcohol use disorder.Alcoholism, clinical and experimental research · 2021Article
- Brain-Behavior Associations for Risk Taking Depend on the Measures Used to Capture Individual Differences.Frontiers in behavioral neuroscience · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewA wealth of epidemiological and cohort research, together with a healthy dose of anecdote, has characterized late-adolescence and emerging adulthood as a time of increased substance use and other risky behaviors. This review will address whether differences between adolescents or between adolescents and other age groups in dopaminergic mesolimbic recruitment by (non-drug) rewards inferred from functional magnetic resonance imaging (fMRI) could partially explain morbidity and mortality from risky-behavior-related causes in adolescents. RECENT
findingsRecent findings do not suggest a definitive directionality with regard to whether increased vs decreased mesolimbic responsiveness to nondrug rewards correlates with real-world risk-taking. Inconsistent relationships between reward-activation and real-world risky behavior in these reports reflect in part methodological differences as well as conceptual differences between populations in terms of whether tepid mesolimbic recruitment by rewards is a marker of psychiatric health. SUMMARY: There are several potential reasons why the directionality of relationships between reward-elicited brain activation and substance use risk (specifically) might differ. These factors include differences between adolescents in histories/exposure of substance use, motivation for substance use, the component of the instrumental behavior being studied, and the cognitive demands of the incentive tasks. Systematic manipulation of these discrepant study factors might offer a way forward to clarify how motivational neurocircuit function relates to addiction risk in adolescents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.