Evidence map›Paper›PMID 33585074›Full record

ArticleCurrent physical medicine and rehabilitation reports2020

Cerebellar Neuromodulation for Stroke.

Jessica Cooperrider, Arbaz Momin, Kenneth B Baker, Andre G Machado

Open access · greenAbstract read
In one paragraph

Article in Current physical medicine and rehabilitation reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Post-trial access to implantable neural devices: an exploratory international survey.BMJ surgery, interventions, & health technologies · 2024
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jessica CooperriderCleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio 44195.
Arbaz MominCleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio 44195.
Kenneth B BakerDepartment of Neurosciences, Cleveland Clinic, Cleveland, OH, 44195.
Andre G MachadoDepartment of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland, OH, 44195.
Cleveland Clinic · USCleveland Clinic Lerner College of Medicine · US

Funding

Deep cerebellar electrical stimulation for post-stroke motor recoveryUH3NS100543 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI BAKER, KENNETH B, MACHADO, ANDRE GUELMAN · 2016 to 2021
$4.9M
Cerebellar deep brain stimulation to enhance chronic post-stroke rehabilitationR01NS105899 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI BAKER, KENNETH B, MACHADO, ANDRE GUELMAN · 2018 to 2022
$2.5M
Dentatothalamocortical electrical stimulation in post-stroke motor recoveryR01HD061363 · NICHD · CLEVELAND CLINIC LERNER COM-CWRU · PI MACHADO, ANDRE GUELMAN · 2010 to 2014
$1.5M
NICHD NIH HHS R01 HD061363NINDS NIH HHS R01 NS105899NINDS NIH HHS UH3 NS100543
6 · The paper itself

Abstract

purpose of reviewThis paper reviews the current preclinical and clinical evidence for cerebellar deep brain stimulation for stroke rehabilitation. RECENT

findingsWe have demonstrated the effectiveness of cerebellar stimulation for stroke rehabilitation in rodent models, which has been reproduced by other groups. Synaptogenesis, neurogenesis, and vicariation of function in the perilesional cortex likely contribute to the mechanistic underpinnings of the effectiveness of this therapy. A Phase I clinical trial investigating dentate nucleus stimulation for improvement of hemiparesis due to stroke is currently underway, and results thus far are encouraging. SUMMARY: Activation of the rodent cerebellar dentate nucleus promotes functional motor recovery following stroke. Although results of a Phase I clinical trial are pending, substantial preclinical evidence indicates that deep brain stimulation of the dentate nucleus is a promising therapeutic modality.

Indexed as

cerebellar stimulationdeep brain stimulationdentate nucleusneurorehabilitationstroke

Identifiers

PMID33585074
PMCPMC7879492
OpenAlexW3008697085

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.