ArticleFrontiers in immunology2020
Persistent Systemic Inflammation in Patients With Severe Burn Injury Is Accompanied by Influx of Immature Neutrophils and Shifts in T Cell Subsets and Cytokine Profiles.
Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Beyond the initial impact: a systematic review of post-traumatic bone loss and its mechanisms.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Pooled it
- Variation of Pro- and Anti-Inflammatory Factors in Severe Burns: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Serious Infections in Burn-Injured Adults: A Retrospective Single-Center Study from 1997 to 2023.Journal of burn care & research : official publication of the American Burn Association · 2026Article
- Targeting Immune Dysregulation After Burn Injury for Improved Healing and Outcomes.Biomolecules · 2026Review
- Murine leukocyte dysfunction in response to a non-lethal flame burn.Infection and immunity · 2026Article
- Immediate post-injury HMGB1 neutralization prevents synaptic dysfunction in burn and hindlimb unloaded rats.Frontiers in immunology · 2026Article
- Fibroblast Dynamics Following Partial and Deep Burn Injury in a Reconstructed Human Skin Model.Tissue engineering and regenerative medicine · 2026Article
- GM-CSF ameliorates inflammation from Pseudomonas aeruginosa in a juvenile mouse model of burn injury.Journal of leukocyte biology · 2025Article
- Mechanisms of extracorporeal shock wave therapy in burn scar repair: Advances in immunoactivation-based scar remodeling research.Regenerative therapy · 2025Review
- Sleep disorder increases risk of psychiatric disorder in burn survivors.Burns : journal of the International Society for Burn Injuries · 2025Article
- Therapeutic Potential of Modulating Gene-MicroRNA Crosstalk in Burn Injury.International journal of molecular sciences · 2025Review
- Shared immune biomarkers in necrotizing enterocolitis and neonatal sepsis identified via bioinformatics and machine learning.Scientific reports · 2025Article
- Pan-Immune Inflammation Value as a Novel Comprehensive Predictor of In-Hospital Mortality in Patients with Severe Burns: A Single-Center Retrospective Analysis.Medicina (Kaunas, Lithuania) · 2025Article
- Sepsis in burn care: incidence and outcomes.Military Medical Research · 2025Article
- Evidence Supporting Conservative Scar Management Interventions Following Burn Injury: A Review Article.Journal of burn care & research : official publication of the American Burn Association · 2025Review
- Early mobilization after skin graft for burn injury in adults.The Cochrane database of systematic reviews · 2025Article
- Immunosenescence in Sepsis: Molecular Mechanisms and Potential Therapeutic Targets.Aging and disease · 2025Review
- Monocyte Anisocytosis Changes in Patients After Major Burn Injuries.Journal of burn care & research : official publication of the American Burn Association · 2025Article
- Post-burns persistent inflammation leads to kidney PANoptosis with Caspases pathway activation.Heliyon · 2025Article
- Systems immunology integrates the complex endotypes of recessive dystrophic epidermolysis bullosa.Nature communications · 2025Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe burn injury causes local and systemic immune responses that can persist up to months, and can lead to systemic inflammatory response syndrome, organ damage and long-term sequalae such as hypertrophic scarring. To prevent these pathological conditions, a better understanding of the underlying mechanisms is essential. In this longitudinal study, we analyzed the temporal peripheral blood immune profile of 20 burn wound patients admitted to the intensive care by flow cytometry and secretome profiling, and compared this to data from 20 healthy subjects. The patient cohort showed signs of systemic inflammation and persistently high levels of pro-inflammatory soluble mediators, such as IL-6, IL-8, MCP-1, MIP-1β, and MIP-3α, were measured. Using both unsupervised and supervised flow cytometry techniques, we observed a continuous release of neutrophils and monocytes into the blood for at least 39 days. Increased numbers of immature neutrophils were present in peripheral blood in the first three weeks after injury (0.1-2.8 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.