Evidence map›Paper›PMID 33584713›Full record

ArticleFrontiers in immunology2020

Inactivation of the PD-1-Dependent Immunoregulation in Mice Exacerbates Contact Hypersensitivity Resembling Immune-Related Adverse Events.

Matin Dokht Ashoori, Kensuke Suzuki, Yosuke Tokumaru, Naoko Ikuta, Masaki Tajima, Tasuku Honjo, Akio Ohta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Matin Dokht AshooriDepartment of Immunology, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Japan.
Kensuke SuzukiDepartment of Immunology, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Japan.
Yosuke TokumaruDepartment of Immunology, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Japan.
Naoko IkutaDepartment of Immunology, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Japan.
Masaki TajimaDepartment of Immunology, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Japan.
Tasuku HonjoDepartment of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Akio OhtaDepartment of Immunology, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Japan.
Foundation for Biomedical Research and Innovation · JPKyoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blockade of PD-1, an indispensable physiological immunoregulatory mechanism, enhances immune activities and is widely used in the immunotherapy of cancer. This treatment often accompanies inflammatory complication called immune-related adverse events (irAE), most frequently in the skin. To analyze how skin inflammation develops by the blockade of PD-1-dependent immunoregulation, we studied the exacerbation of oxazolone-induced contact hypersensitivity by PD-L1 blockade. The inactivation of PD-1 signaling enhanced swelling of the skin with massive CD8

Indexed as

Adjuvants, ImmunologicAnimalsCD8-Positive T-LymphocytesDermatitis, ContactDisease Models, AnimalImmune Checkpoint InhibitorsMiceMice, Inbred C57BLOxazoloneProgrammed Cell Death 1 ReceptorReceptors, CXCR3Adjuvants, ImmunologicCxcr3 protein, mouseImmune Checkpoint InhibitorsOxazolonePdcd1 protein, mouseProgrammed Cell Death 1 ReceptorReceptors, CXCR3cancer immunotherapycontact hypersensitivityCXCR3immune-related adverse eventsPD-1skinT cells

Identifiers

PMID33584713
PMCPMC7873368
OpenAlexW3125222955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.