Evidence map›Paper›PMID 33584680›Full record

ArticleFrontiers in immunology2020

Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells.

Vikas Duhan, Vishal Khairnar, Simo Kitanovski, Thamer A Hamdan, Andrés D Klein, Judith Lang, Murtaza Ali, Tom Adomati, Hilal Bhat, Sarah-Kim Friedrich and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 7 countries.

Vikas DuhanInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Vishal KhairnarInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Simo KitanovskiBioinformatics and Computational Biophysics, Faculty of Biology, University of Duisburg-Essen, Essen, Germany.
Thamer A HamdanInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Andrés D KleinDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Judith LangInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Murtaza AliInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Tom AdomatiInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Hilal BhatInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Sarah-Kim FriedrichInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Fanghui LiInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Philippe KrebsInstitute of Pathology, University of Bern, Bern, Switzerland.
Anthony H FutermanDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Marylyn M AddoUniversity Medical Center Hamburg-Eppendorf, Division of Infectious Diseases, 1st Department of Medicine, Hamburg, Germany.
Cornelia HardtInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Daniel HoffmannBioinformatics and Computational Biophysics, Faculty of Biology, University of Duisburg-Essen, Essen, Germany.
Philipp A LangDepartment of Molecular Medicine II, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Karl S LangInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
University of Duisburg-Essen · DEAmerican University of Madaba · JODana-Farber Cancer Institute · USHeinrich Heine University Düsseldorf · DEUniversidad del Desarrollo · CLUniversität Hamburg · DEUniversity Hospital Cologne · DEUniversity of Bern · CHWeizmann Institute of Science · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early and strong production of IFN-I by dendritic cells is important to control vesicular stomatitis virus (VSV), however mechanisms which explain this cell-type specific innate immune activation remain to be defined. Here, using a genome wide association study (GWAS), we identified Integrin alpha-E (

Indexed as

Immunity, InnateAnimalsAntigens, CDCells, CulturedDendritic CellsDisease Models, AnimalGenome-Wide Association StudyHost-Pathogen InteractionsIntegrin alpha ChainsInterferon Type IMiceMice, 129 StrainMice, Inbred AKRMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLalpha E integrinsAntigens, CDIfnar1 protein, mouseIntegrin alpha ChainsInterferon Type ImTOR protein, mouseProto-Oncogene Proteins c-aktReceptor, Interferon alpha-betaTOR Serine-Threonine KinasesAKTCD103genome wide association screenGWASIFN-IItgaemTORvesicular stomatitis virus

Identifiers

PMID33584680
PMCPMC7873973
OpenAlexW3124110203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.