Evidence map›Paper›PMID 33584648›Full record

ArticleFrontiers in immunology2020

Translation of IRF-1 Restricts Hepatic Interleukin-7 Production to Types I and II Interferons: Implications for Hepatic Immunity.

Sabrina Rueschenbaum, Chengcong Cai, Matthias Schmidt, Katharina Schwarzkopf, Ulf Dittmer, Stefan Zeuzem, Christoph Welsch, Christian M Lange

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. The Role of Interferon Regulatory Factors in Liver Diseases.International journal of molecular sciences · 2024
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sabrina RueschenbaumDepartment of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Chengcong CaiDepartment of Medicine 1, J.W. Goethe University Hospital, Frankfurt, Germany.
Matthias SchmidtDepartment of Medicine 1, J.W. Goethe University Hospital, Frankfurt, Germany.
Katharina SchwarzkopfDepartment of Medicine 1, J.W. Goethe University Hospital, Frankfurt, Germany.
Ulf DittmerInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Stefan ZeuzemDepartment of Medicine 1, J.W. Goethe University Hospital, Frankfurt, Germany.
Christoph WelschDepartment of Medicine 1, J.W. Goethe University Hospital, Frankfurt, Germany.
Christian M LangeDepartment of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Goethe University Frankfurt · DEUniversity Hospital Frankfurt · DEUniversity of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin-7 (IL-7) is an important cytokine with pivotal pro-survival functions in the adaptive immune system. However, the role of IL-7 in innate immunity is not fully understood. In the present study, the impact of hepatic IL-7 on innate immune cells was assessed by functional experiments as well as in patients with different stages of liver cirrhosis or acute-on-chronic liver failure (ACLF). Human hepatocytes and liver sinusoidal endothelial cells secreted IL-7 in response to stimulation with interferons (IFNs) of type I and II, yet not type III.

Indexed as

Acute-On-Chronic Liver FailureCell LineCoculture TechniquesCohort StudiesGlycogen Synthase Kinase 3HepatocytesHep G2 CellsHumansImmunity, InnateInterferon-gammaInterferon Regulatory Factor-1Interferon Type IInterleukin-7LiverLiver CirrhosisMacrophagesGlycogen Synthase Kinase 3IL7 protein, humanInterferon-gammaInterferon Regulatory Factor-1Interferon Type IInterleukin-7acute-on-chronic liver failurecytokinesinflammationinterferonsliver cirrhosisliver immunologymacrophages

Identifiers

PMID33584648
PMCPMC7874116
OpenAlexW3119999228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.