Evidence map›Paper›PMID 33584643›Full record

ArticleFrontiers in immunology2020

Impact of a Rapid Decline in Malaria Transmission on Antimalarial IgG Subclasses and Avidity.

Isaac Ssewanyana, John Rek, Isabel Rodriguez, Lindsey Wu, Emmanuel Arinaitwe, Joaniter I Nankabirwa, James G Beeson, Harriet Mayanja-Kizza, Philip J Rosenthal, Grant Dorsey and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
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  10. Natural killer cell antibody-dependent cellular cytotoxicity toClinical & translational immunology · 2024
    Article
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  15. Assessment of IgG3 as a serological exposure marker forFrontiers in cellular and infection microbiology · 2022
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 4 countries.

Isaac SsewanyanaInfectious Diseases Research Collaboration, Kampala, Uganda.
John RekInfectious Diseases Research Collaboration, Kampala, Uganda.
Isabel RodriguezDepartment of Medicine, University of California San Francisco, San Francisco, CA, United States.
Lindsey WuDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Emmanuel ArinaitweInfectious Diseases Research Collaboration, Kampala, Uganda.
Joaniter I NankabirwaInfectious Diseases Research Collaboration, Kampala, Uganda.
James G BeesonBurnet Institute, Melbourne, VIC, Australia.
Harriet Mayanja-KizzaSchool of Medicine, Makerere University, Kampala, Uganda.
Philip J RosenthalDepartment of Medicine, University of California San Francisco, San Francisco, CA, United States.
Grant DorseyDepartment of Medicine, University of California San Francisco, San Francisco, CA, United States.
Moses R KamyaInfectious Diseases Research Collaboration, Kampala, Uganda.
Chris DrakeleyDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Bryan GreenhouseDepartment of Medicine, University of California San Francisco, San Francisco, CA, United States.
Kevin K A TettehDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
London School of Hygiene & Tropical Medicine · GBUniversity of California, San Francisco · USInfectious Diseases Research Collaboration · UGMakerere University · UGMonash University · AU

Funding

Transmission ProjectU19AI089674 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joaniter Immaculate Nankabirwa · 2010 to 2026
$29.3M
NIAID NIH HHS U19 AI089674
6 · The paper itself

Abstract

Understanding how immunity to malaria is affected by declining transmission is important to aid vaccine design and understand disease resurgence. Both IgG subclasses and avidity of antigen-specific responses are important components of an effective immune response. Using a multiplex bead array assay, we measured the total IgG, IgG subclasses, and avidity profiles of responses to 18

Indexed as

AdolescentAdultAgingAntibodies, ProtozoanAntibody AffinityAntigens, ProtozoanChildChild, PreschoolDisease Transmission, InfectiousHumansImmunity, HumoralImmunoglobulin GInfantMalaria, FalciparumMalaria VaccinesPlasmodium falciparumAntibodies, ProtozoanAntigens, ProtozoanImmunoglobulin GMalaria Vaccinesantibody avidityavidity indexIgG subclass antibodiesimmunitymalariaPlasmodium falciparum

Identifiers

PMID33584643
PMCPMC7873448
OpenAlexW3122399033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.