ArticleFrontiers in microbiology2021
Thymine Sensitizes Gram-Negative Pathogens to Antibiotic Killing.
Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Sequential eradication of bacterial persisters: integrating phytochemical pharmacology with microenvironment-responsive delivery strategies.Frontiers in microbiology · 2026Review
- Antibacterial and Anti-virulence Properties of Cell-free Supernatant from a Mixture of Limosilactobacillus fermentum Strains Against Enterotoxigenic Escherichia coli.Probiotics and antimicrobial proteins · 2025Article
- Article
- Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters.Science advances · 2025Article
- Vitamin B6 resensitizes mcr-carrying Gram-negative bacteria to colistin.Communications biology · 2025Article
- Repurposing zidovudine and 5-fluoro-2'-deoxyuridine as antibiotic drugs made possible by synergy with both trimethoprim and the mitochondrial toxicity-reducing agent uridine.The Journal of antimicrobial chemotherapy · 2025Article
- Multi-omics dissection of metabolic dysregulation associated with immune recovery in people living with HIV-1.Journal of translational medicine · 2025Article
- Phytochemical Isolation and Antimicrobial, Thrombolytic, Anti-inflammatory, Analgesic, and Antidiarrheal Activities from the Shell of Commonly AvailableNutrition and metabolic insights · 2025Article
- Metabolic response of Klebsiella oxytoca to ciprofloxacin exposure: a metabolomics approach.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Exogenous NADH promotes the bactericidal effect of aminoglycoside antibiotics againstVirulence · 2024Article
- Inosine reverses multidrug resistance in Gram-negative bacteria carrying mobilized RND-type efflux pump gene clustermSystems · 2024Article
- Deciphering the Antibacterial Mechanisms of 5-Fluorouracil inAntibiotics (Basel, Switzerland) · 2024Article
- Purine and pyrimidine synthesis differently affect the strength of the inoculum effect for aminoglycoside and β-lactam antibiotics.bioRxiv : the preprint server for biology · 2024Article
- Article
- Fructose promotes ampicillin killing of antibiotic-resistantVirulence · 2023Article
- The Combination of Antibiotic and Non-Antibiotic Compounds Improves Antibiotic Efficacy against Multidrug-Resistant Bacteria.International journal of molecular sciences · 2023Review
- Baicalein Resensitizes Multidrug-Resistant Gram-Negative Pathogens to Doxycycline.Microbiology spectrum · 2023Article
- Administration ofmedRxiv : the preprint server for health sciences · 2023Article
- Administration ofFrontiers in microbiology · 2023Article
- Alkaline arginine promotes the gentamicin-mediated killing of drug-resistantFrontiers in microbiology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diminished antibiotic susceptibility of bacterial pathogens is an increasingly serious threat to human and animal health. Alternative strategies are required to combat antibiotic refractory bacteria. Bacterial metabolic state has been shown to play a critical role in its susceptibility to antibiotic killing. However, the adjuvant potential of nucleotides in combination with antibiotics to kill Gram-negative pathogens remains unknown. Herein, we found that thymine potentiated ciprofloxacin killing against both sensitive and resistant-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.