Evidence map›Paper›PMID 33584499›Full record

ArticleFrontiers in neurology2020

Case Report: Posterior Reversible Leukoencephalopathy Syndrome (PRES) as a Biologically Predictable Neurological Association in Severe COVID-19. First Reported Case From Australia and Review of Internationally Published Cases.

Tissa Wijeratne, Chanith Wijeratne, Leila Karimi, Carmela Sales, Sheila Gillard Crewther

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
  5. Review
  6. Observational
  7. Review
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Tissa WijeratneSchool of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia.
Chanith WijeratneDepartment of Neurology, Western Health & University Melbourne, Australian Institute for Musculoskeletal Science (AIMSS), Western Centre for Health Research & Education (WHCRE), Sunshine Hospital, St Albans, VIC, Australia.
Leila KarimiSchool of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia.
Carmela SalesDepartment of Neurology, Western Health & University Melbourne, Australian Institute for Musculoskeletal Science (AIMSS), Western Centre for Health Research & Education (WHCRE), Sunshine Hospital, St Albans, VIC, Australia.
Sheila Gillard CrewtherSchool of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia.
Sunshine Hospital · AUWestern Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reports of different types of neurological manifestations of COVID-19 are rapidly increasing, including changes of posterior reversible leukoencephalopathy syndrome (PRES). Here we describe the first reported case of COVID-19 and PRES in Australia diagnosed on basis of MRI brain imaging and confirmed clinically by presence of confusion, delirium, headaches, also associated with hypertension and blood pressure variability and stable long-term kidney problems. He made full recovery as his blood pressure was controlled and clinical status was supported with appropriate supportive therapy. Although traditionally a rare condition, PRES is likely to be more common among patients with COVID-19 pathobiology there is Renin downregulation of ACE2 receptors, involvement of Renin-Angiotensin-Aldosterone system, endotheliitis, cytokine storm, and hyper-immune response. Thus we advocate clinical suspicion and early brain imaging with MRI brain among vulnerable patients with known co-morbidities, and diagnosed with COVID-19 given that hypertension and blood pressure variability are often exacerbated by acute SARS-CoV-2 immune reactions. Such acute hypertensive encephalopathy was able to be reversed with timely supportive therapy ensuring re-hydration and re-establishment of blood pressure control.

Indexed as

case reportCOVID-19hypertensionposterior reversible encephalopathy syndrome (PRES)SARS-CoV-2

Identifiers

PMID33584499
PMCPMC7875083
OpenAlexW3123695894

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.