Evidence map›Paper›PMID 33584494›Full record

ArticleFrontiers in neurology2020

Association Between BDNF Val66Met Polymorphism and Mild Behavioral Impairment in Patients With Parkinson's Disease.

Mehrafarin Ramezani, Jennifer A Ruskey, Kristina Martens, Mekale Kibreab, Zainul Javer, Iris Kathol, Tracy Hammer, Jenelle Cheetham, Etienne Leveille, Davide Martino and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Disruption of BDNF signalling in neuropathologies.Biochemical Society transactions · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Behavioral disorders in Parkinson disease: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Neuroimaging of mild behavioral impairment: A systematic review.PCN reports : psychiatry and clinical neurosciences · 2023
    Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Brain-derived Neurotrophic Factor and Its Applications through Nanosystem Delivery.Iranian journal of pharmaceutical research : IJPR · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Mehrafarin RamezaniDepartment of Clinical Neuroscience, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Jennifer A RuskeyMontreal Neurological Institute, McGill University, Montreal, QC, Canada.
Kristina MartensDepartment of Clinical Neuroscience, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Mekale KibreabDepartment of Clinical Neuroscience, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Zainul JaverDepartment of Clinical Neuroscience, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Iris KatholDepartment of Clinical Neuroscience, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Tracy HammerDepartment of Clinical Neuroscience, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Jenelle CheethamDepartment of Clinical Neuroscience, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Etienne LeveilleMontreal Neurological Institute, McGill University, Montreal, QC, Canada.
Davide MartinoDepartment of Clinical Neuroscience, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Justyna R SarnaDepartment of Clinical Neuroscience, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Ziv Gan-OrMontreal Neurological Institute, McGill University, Montreal, QC, Canada.
Gerald PfefferDepartment of Clinical Neuroscience, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Zahinoor IsmailDepartment of Clinical Neuroscience, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Oury MonchiDepartment of Clinical Neuroscience, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
University of Calgary · CAMcGill University · CAMontreal Neurological Institute and Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuropsychiatric symptoms (NPS) are common in Parkinson's disease (PD) and have demonstrated an association with the p. Val66Met, a polymorphism in the

Indexed as

BDNFdepressionmild behavioral impairmentneuropsychiatric symptomsParkinson's disease

Identifiers

PMID33584494
PMCPMC7874164
OpenAlexW3118583305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.