Evidence map›Paper›PMID 33584250›Full record

ArticleFrontiers in aging neuroscience2021

New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases.

Johannes Boltze, Jaroslaw A Aronowski, Jerome Badaut, Marion S Buckwalter, Mateo Caleo, Michael Chopp, Kunjan R Dave, Nadine Didwischus, Rick M Dijkhuizen, Thorsten R Doeppner and 46 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. An enriched environment improves long-term functional outcomes in mice after intracerebral hemorrhage by mechanisms that involve the Nrf2/BDNF/glutaminase pathway.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  3. Article
  4. Expression of DEspR in acute intracerebral hemorrhage.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022
    Observational
  5. Review
  6. Article
  7. Phenotype Shifting in Astrocytes Account for Benefits of Intra-Arterial Selective Cooling Infusion in Hypertensive Rats of Ischemic Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

56 authors at 20 institutions in 14 countries.

Johannes BoltzeSchool of Life Sciences, University of Warwick, Warwick, United Kingdom.
Jaroslaw A AronowskiInstitute for Stroke and Cerebrovascular Diseases, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Jerome BadautNRS UMR 5287, INCIA, Brain Molecular Imaging Team, University of Bordeaux, Bordeaux cedex, France.
Marion S BuckwalterDepartments of Neurology and Neurological Sciences, and Neurosurgery, Wu Tsai Neurosciences Institute, Stanford School of Medicine, Stanford, CA, United States.
Mateo CaleoNeuroscience Institute, National Research Council, Pisa, Italy.
Michael ChoppDepartment of Neurology, Henry Ford Hospital, Detroit, MI, United States.
Kunjan R DavePeritz Scheinberg Cerebral Vascular Disease Research Laboratory, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, United States.
Nadine DidwischusSchool of Life Sciences, University of Warwick, Warwick, United Kingdom.
Rick M DijkhuizenBiomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands.
Thorsten R DoeppnerDepartment of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Jens P DreierDepartment of Neurology, Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Karim FouadFaculty of Rehabilitation Medicine and Institute for Neuroscience and Mental Health, University of Alberta, Edmonton, AB, Canada.
Mathias GelderblomDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Karen GertzDepartment of Neurology, Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Dominika GolubczykDepartment of Neurosurgery, School of Medicine, University of Warmia and Mazury, Olsztyn, Poland.
Barbara A GregsonNeurosurgical Trials Group, Institute of Neuroscience, The University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.
Edith HamelLaboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Daniel F HanleyDivision of Brain Injury Outcomes, Johns Hopkins University, Baltimore, MD, United States.
Wolfgang HärtigPaul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany.
Friedhelm C HummelClinical Neuroengineering, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology Valais, Clinique Romande de Réadaptation, Sion, Switzerland.
Maulana IkhsanInstitute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.
Miroslaw JanowskiDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States.
Jukka JolkkonenDepartment of Neurology, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Saravanan S KaruppagounderBurke Neurological Institute, White Plains, NY, United States.
Richard F KeepDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, United States.
Inga K KoertePsychiatric Neuroimaging Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Zaal KokaiaLund Stem Cell Center, Lund University, Lund, Sweden.
Peiying LiDepartment of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Fudong LiuDepartment of Neurology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, United States.
Ignacio LizasoainUnidad de Investigación Neurovascular, Departamento Farmacología y Toxicología, Facultad de Medicina, Instituto Universitario de Investigación en Neuroquímica, Universidad Complutense de Madrid, Madrid, Spain.
Peter LudewigDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Gerlinde A S MetzDepartment of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada.
Axel MontagneZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Andre ObenausDepartment of Pediatrics, University of California, Irvine, Irvine, CA, United States.
Alex PalumboInstitute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.
Monica PearlThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Miguel Perez-PinzonPeritz Scheinberg Cerebral Vascular Disease Research Laboratory, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, United States.
Anna M PlanasInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Àrea de Neurociències, Barcelona, Spain.
Nikolaus PlesnilaInstitute for Stroke and Dementia Research (ISD), Munich University Hospital, Munich, Germany.
Ami P RavalPeritz Scheinberg Cerebral Vascular Disease Research Laboratory, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, United States.
Maria A RuegerFaculty of Medicine and University Hospital, Department of Neurology, University of Cologne, Cologne, Germany.
Lauren H SansingDepartment of Neurology, Yale University School of Medicine, New Haven, CT, United States.
Farida SohrabjiWomen's Health in Neuroscience Program, Neuroscience and Experimental Therapeutics, Texas A&M College of Medicine, Bryan, TX, United States.
Charlotte J StaggNuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom.
R Anne StetlerDepartment of Neurology, Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh, Pittsburgh, PA, United States.
Ann M StoweDepartment of Neurology and Neurotherapeutics, Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, United States.
Dandan SunPittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, PA, United States.
Akihiko TaguchiDepartment of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan.
Mickael TanterInstitute of Physics for Medicine Paris, INSERM U1273, ESPCI Paris, CNRS FRE 2031, PSL University, Paris, France.
Sabine U VayFaculty of Medicine and University Hospital, Department of Neurology, University of Cologne, Cologne, Germany.
Raghu VemugantiDepartment of Neurological Surgery, University of Wisconsin, Madison, WI, United States.
Denis VivienUNICAEN, INSERM, INSERM UMR-S U1237, Physiopathology and Imaging for Neurological Disorders (PhIND), Normandy University, Caen, France.
Piotr WalczakDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States.
Jian WangDepartment of Human Anatomy, College of Medical Sciences, Zhengzhou University, Zhengzhou, China.
Ye XiongDepartment of Neurosurgery, Henry Ford Hospital, Detroit, MI, United States.
Marietta ZilleInstitute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.
University of Miami · USHenry Ford Hospital · USJohns Hopkins University · USThe University of Texas Health Science Center at Houston · USUniversity of Cologne · DEUniversity of Lübeck · DEUniversity of Maryland, Baltimore · USUniversity of Pittsburgh · USUniversity of Warwick · GBBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEBernstein Center for Computational Neuroscience Berlin · DEBrigham and Women's Hospital · USBurke Medical Research Institute · USClinique Romande de Réadaptation · CHConsejo Superior de Investigaciones Científicas · ESESPCI Paris · FRFoundation for Biomedical Research and Innovation · JPFraunhofer Research Institution for Individualized and Cell-Based Medical Engineering · DELeipzig University · DELund University · SE

Funding

Contribution of the X Chromosome to Sex Differences in StrokeR01NS108779 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LIU, FUDONG, MCCULLOUGH, LOUISE D. · 2018 to 2022
$2.7M
NINDS NIH HHS R01 NS108779
6 · The paper itself

Abstract

The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially paving the way for a renaissance of neuroprotectants. Progress in basic science has been equally impressive. Based on a deeper understanding of pathomechanisms underlying cerebrovascular diseases, new therapeutic targets have been identified and novel treatment strategies such as pre- and post-conditioning methods were developed. Moreover, translationally relevant aspects are increasingly recognized in basic science studies, which is believed to increase their predictive value and the relevance of obtained findings for clinical application.This review reports key results from some of the most remarkable and encouraging achievements in neurovascular research that have been reported at the 10th International Symposium on Neuroprotection and Neurorepair. Basic science topics discussed herein focus on aspects such as neuroinflammation, extracellular vesicles, and the role of sex and age on stroke recovery. Translational reports highlighted endovascular techniques and targeted delivery methods, neurorehabilitation, advanced functional testing approaches for experimental studies, pre-and post-conditioning approaches as well as novel imaging and treatment strategies. Beyond ischemic stroke, particular emphasis was given on activities in the fields of traumatic brain injury and cerebral hemorrhage in which promising preclinical and clinical results have been reported. Although the number of neutral outcomes in clinical trials is still remarkably high when targeting cerebrovascular diseases, we begin to evidence stepwise but continuous progress towards novel treatment options. Advances in preclinical and translational research as reported herein are believed to have formed a solid foundation for this progress.

Indexed as

cell therapiesdementiaexperimental therapyhemorrhageneuroprotectionneurorehabilitationstroketranslational research

Identifiers

PMID33584250
PMCPMC7876251
OpenAlexW3128471551

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.