ReviewFrontiers in behavioral neuroscience2020
The Contribution of Physical Exercise to Brain Resilience.
Review in Frontiers in behavioral neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06955676 (The Effects of Moderate Intensity, Time-matched Cycle Ergometer vs. Treadmill Exercise Training on Parameters Associated With Physiological Resilience in Older Adults), which is not on this map. Cited by 84 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Moderate Intensity, Time-matched Cycle Ergometer vs. Treadmill Exercise Training on Parameters Associated With Physiological Resilience in Older Adults: A Pilot Study
Who cites it
84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Nature-based and technology-assisted exercise for cognitive and mobility outcomes in older adults: a systematic review of randomized trials.BMC geriatrics · 2026Pooled it
- Association between neuroticism and physical activity: a systematic review and meta-analysis.Frontiers in human neuroscience · 2025Pooled it
- Effectiveness of Mobile-Delivered Exercise and Yoga Programs on Depressive Symptom Reduction in Employees: Randomized Controlled Trial.JMIR human factors · 2026Trial
- Accelerated Brain Aging Identifies Functional Vulnerability Beyond Chronological Age in Multiple Sclerosis.Sensors (Basel, Switzerland) · 2026Trial
- The effect of regular exercise on general and mental fatigue and motivation during pregnancy: a randomized controlled trial.BMC pregnancy and childbirth · 2026Trial
- Factors associated with the risk of falls and their relationship with cognitive function in older adults with cognitive impairment: a cross-sectional study.GeroScience · 2026Article
- Exercise-induced neuropeptidergic and neurochemical neuroadaptation in stress regulation and emotional disorders.Acta neurologica Belgica · 2026Review
- Article
- A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026Review
- Associations Among Demographic Characteristics, Sleep Behaviors, Physical Activity, Health Status, and Quality of Life Among Undergraduate Students: A Structural Equation Modeling Study.Healthcare (Basel, Switzerland) · 2026Article
- How Life-Course Trajectories of Physical Activity Track With Cognitive Decline.Journal of physical activity & health · 2026Article
- Physical Activity and Purkinje Cells: Mechanisms of Cerebellar Plasticity and Neuroprotection.Journal of functional morphology and kinesiology · 2026Review
- Association Between Physical Activity and Mental Health in Primary School Children.Sports (Basel, Switzerland) · 2026Article
- Accessibility to urban parks and resilience among adults in Spain: gender inequalities from the DESVELA study.BMC public health · 2026Article
- Exercise-associated microRNA programs as candidate modulators and biomarkers in glioblastoma: a narrative review.Discover oncology · 2026Review
- Adolescents Who Are Overweight or Obese Exhibit Weaker Spatial and Verbal Working Memory Compared with Healthy-Weight Peers.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- Bridging reward and resilience: the endocannabinoid system as a unifying mechanism in exercise-induced protection against major depressive disorder.Frontiers in psychiatry · 2026Review
- Outline: The Long-Term Impact of Exercise on Adolescent Growth and Development.Advances in experimental medicine and biology · 2026Review
- The relationship between physical activity and academic burnout among Yi primary school students in Southwest China: a moderated chain-mediation model.Frontiers in psychology · 2026Article
- Risk perception and neuro-emotional development in adolescent athletes: psychometric validation of the ESTUDES scales for preventive guidance contexts.Frontiers in psychology · 2026Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing attention has been given to understanding resilience to brain diseases, often described as brain or cognitive reserve. Among the protective factors for the development of resilience, physical activity/exercise has been considered to play an important role. Exercise is known to induce many positive effects on the brain. As such, exercise represents an important tool to influence neurodevelopment and shape the adult brain to react to life's challenges. Among many beneficial effects, exercise intervention has been associated with cognitive improvement and stress resilience in humans and animal models. Thus, a growing number of studies have demonstrated that exercise not only recovers or minimizes cognitive deficits by inducing better neuroplasticity and cognitive reserve but also counteracts brain pathology. This is evidenced before disease onset or after it has been established. In this review, we aimed to present encouraging data from current clinical and pre-clinical neuroscience research and discuss the possible biological mechanisms underlying the beneficial effects of physical exercise on resilience. We consider the implication of physical exercise for resilience from brain development to aging and for some neurological diseases. Overall, the literature indicates that brain/cognitive reserve built up by regular exercise in several stages of life, prepares the brain to be more resilient to cognitive impairment and consequently to brain pathology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.