Evidence map›Paper›PMID 33584172›Full record

ArticleFrontiers in neuroscience2020

Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain.

Meng He, Kun Qian, Ying Zhang, Xu-Feng Huang, Chao Deng, Baohua Zhang, Guanbin Gao, Jing Li, Hao Xie, Taolei Sun

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  5. The Janus face of antipsychotics in glial cells: Focus on glioprotection.Experimental biology and medicine (Maywood, N.J.) · 2023
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Meng HeSchool of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, China.
Kun QianSchool of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, China.
Ying ZhangSchool of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, China.
Xu-Feng HuangSchool of Medicine and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.
Chao DengSchool of Medicine and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.
Baohua ZhangBeijing HuiLongGuan Hospital, Peking University, Beijing, China.
Guanbin GaoState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, China.
Jing LiSchool of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, China.
Hao XieSchool of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, China.
Taolei SunSchool of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, China.
Wuhan University of Technology · CNUniversity of Wollongong · AUPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The antipsychotic drug olanzapine is associated with serious obesity side effects. Hypothalamic astrocytes and associated toll-like receptor-4 (TLR4) signaling play an essential role in obesity pathogenesis. This study investigated the effect of olanzapine on astrocytes and TLR4 signaling both

Indexed as

antipsychoticsendoplasmic reticulum stressglial fibrillary acidic proteinS100 calcium binding protein BTLR4-MyD88 signalingweight gain

Identifiers

PMID33584172
PMCPMC7874166
OpenAlexW3119081351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.