Evidence map›Paper›PMID 33584084›Full record

ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2020

Exploring 1-adamantanamine as an alternative amine moiety for metabolically labile azepane ring in newly synthesized benzo[

Sebastiano Intagliata, Hebaalla Agha, Theresa A Kopajtic, Jonathan L Katz, Shyam H Kamble, Abhisheak Sharma, Bonnie A Avery, Christopher R McCurdy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. UPLC-MS/MS method for the quantification of MCI-77, a novel sigma-1 receptor ligand, and its application to pharmacokinetic studies.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2022
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sebastiano IntagliataDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA.
Hebaalla AghaDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA.
Theresa A KopajticPsychobiology Section, Intramural Research Program, Department of Health and Human Services, NIDA, NIH, Baltimore, MD 21224, USA.
Jonathan L KatzPsychobiology Section, Intramural Research Program, Department of Health and Human Services, NIDA, NIH, Baltimore, MD 21224, USA.
Shyam H KambleDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA.
Abhisheak SharmaDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA.
Bonnie A AveryDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA.
Christopher R McCurdyDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA.

Funding

Novel Pharmacologic Interventions for Drugs of AbuseR01DA023205 · NIDA · UNIVERSITY OF MISSISSIPPI · PI MCCURDY, CHRISTOPHER R · 2007 to 2011
$1.7M
NIDA NIH HHS R01 DA023205
6 · The paper itself

Abstract

In this work we report the structure-activity relationships, binding properties, and metabolic stability studies of a series of benzo[

Indexed as

1-AdamantamineBenzo[d]thiazol-2(3H)oneBinding propertiesMetabolic stabilitySigma receptorsSigma receptors ligandsSoft spot identificationSynthesis

Identifiers

PMID33584084
PMCPMC7880169

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.