ArticleJournal of maxillofacial and oral surgery2021
Is Salivary Sialic Acid a Reliable Biomarker in the Detection of Oral Potentially Malignant Disorder and Oral Squamous Cell Carcinoma.
Article in Journal of maxillofacial and oral surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Salivary Sialic Acid Levels as a Biomarker for Early Detection of Oral Precancer and Oral Cancer: Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2025Pooled it
- Expression of 9-Life (Basel, Switzerland) · 2025Article
- The Global Trends and Advances in Oral Microbiome Research on Oral Squamous Cell Carcinoma: A Systematic Review.Microorganisms · 2025Review
- Diversity and compositional differences in the oral microbiome of oral squamous cell carcinoma patients and healthy controls: a scoping review.Frontiers in oral health · 2024Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGlycoprotein is an important constituent of saliva, and the observed increase in salivary glycoproteins such as sialic acid in oral potentially malignant disorder (OPMDs) and OSCC has stimulated the interest of researchers to explore it as a possible biomarker.
methodsThe study used 60 subjects, who were divided into three groups: Group I-20 subjects who were clinically and histopathologically diagnosed with OSCC; Group II-20 subjects who were clinically and histopathologically diagnosed with OPMDs; and Group III-20 healthy subjects with good oral hygiene and with no systemic disorders detected. Two millilitres of unstimulated salivary samples was collected in a pre-sterilized container to analyse total salivary sialic acid (TSA) levels using a sialic acid kit and UV spectrophotometer.
resultsThe TSA levels in OSCC (545.45 ± 100.04) were much higher when compared to the level in OPMDs (169.80 ± 66.43) and in healthy subjects (25.45 ± 16.07). Statically significant correlation was observed between different grades of OSCC. Moreover, sialic acid showed 100% sensitivity and specificity between all the three groups. Statistical analysis was done with Kruskal-Wallis, followed by Mann-Whitney post hoc test at
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Registered trials
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