Evidence map›Paper›PMID 33583931›Full record

ArticleInternal medicine (Tokyo, Japan)2021

Factors Associated with Hepatitis B Surface Antigen Kinetics and Responses in Pegylated Interferon Alpha-2a Monotherapy for Patients with Chronic Hepatitis B.

Norio Itokawa, Masanori Atsukawa, Akihito Tsubota, Noritomo Shimada, Hidenori Toyoda, Koichi Takaguchi, Atsushi Hiraoka, Tomonori Senoh, Mai Koeda, Yuji Yoshida and 6 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Norio ItokawaDivision of Gastroenterology, Department of Internal Medicine, Nippon Medical School Chiba Hokusoh Hospital, Japan.
Masanori AtsukawaDivision of Gastroenterology, Department of Internal Medicine, Nippon Medical School Chiba Hokusoh Hospital, Japan.
Akihito TsubotaCore Research Facilities, The Jikei University School of Medicine, Japan.
Noritomo ShimadaDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Otakanomori Hospital, Japan.
Hidenori ToyodaDepartment of Gastroenterology, Ogaki Municipal Hospital, Japan.
Koichi TakaguchiDepartment of Hepatology, Kagawa Prefectural Central Hospital, Japan.
Atsushi HiraokaGastroenterology Center, Ehime Prefectural Central Hospital, Japan.
Tomonori SenohDepartment of Hepatology, Kagawa Prefectural Central Hospital, Japan.
Mai KoedaDivision of Gastroenterology, Department of Internal Medicine, Nippon Medical School Chiba Hokusoh Hospital, Japan.
Yuji YoshidaDivision of Gastroenterology, Department of Internal Medicine, Nippon Medical School Chiba Hokusoh Hospital, Japan.
Tomomi OkuboDivision of Gastroenterology, Department of Internal Medicine, Nippon Medical School Chiba Hokusoh Hospital, Japan.
Taeang AraiDivision of Gastroenterology, Department of Internal Medicine, Nippon Medical School Chiba Hokusoh Hospital, Japan.
Korenobu HayamaDivision of Gastroenterology, Department of Internal Medicine, Nippon Medical School Chiba Hokusoh Hospital, Japan.
Ai Nakagawa-IwashitaDivision of Gastroenterology, Department of Internal Medicine, Nippon Medical School Chiba Hokusoh Hospital, Japan.
Chisa KondoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School, Japan.
Katsuhiko IwakiriDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School, Japan.
Chiba Hokusou Hospital · JPKagawa Prefectural Central Hospital · JPNippon Medical School · JPEhime Prefectural Central Hospital · JPJikei University School of Medicine · JPOgaki Municipal Hospital · JPOtemae Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective Pegylated-interferon monotherapy is the standard treatment for patients with chronic hepatitis B; however, the factors associated with its therapeutic effects remain unclear. Methods Patients with chronic hepatitis B were treated with pegylated interferon α-2a for 48 weeks. We evaluated the kinetics of hepatitis B surface antigen (HBsAg) during treatment and follow-up periods and the factors associated with an HBsAg response (defined as a change in HBsAg of ≥-1 log IU/mL from baseline). Results The study population comprised 50 patients. The median baseline levels of hepatitis B virus DNA and HBsAg were 5.00 and 3.40 log IU/mL. The median values of HBsAg reduction from baseline were -0.44 (n=48), -0.41 (n=40), and -0.68 (n=11) log IU/mL at the end of treatment and at 48 and 144 weeks post-treatment, respectively. The rates of HBsAg response were 24.0% and 22.5% at the end of treatment and at 48 weeks post-treatment, respectively. A multivariate analysis identified HBsAg <3.00 log IU/mL as an independent baseline factor contributing to the HBsAg response at the end of treatment and 48 weeks post-treatment (p=1.07×10

Indexed as

Hepatitis B, ChronicHepatitis B Surface AntigensAntiviral AgentsDNA, ViralHepatitis B e AntigensHumansInterferon-alphaKineticsPolyethylene GlycolsRecombinant ProteinsTreatment OutcomeAntiviral AgentsDNA, ViralHepatitis B e AntigensHepatitis B Surface AntigensInterferon-alphaPolyethylene GlycolsRecombinant ProteinsHBsAg responsehepatitis B surface antigen (HBsAg) kineticspegylated interferon alpha-2a monotherapy

Identifiers

PMID33583931
PMCPMC7946504
OpenAlexW3129953464

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.