ReviewJournal of atherosclerosis and thrombosis2021
Is Stiffness Parameter β Useful for the Evaluation of Atherosclerosis?~ Its Clinical Implications, Limitations, and Future Perspectives ~.
Review in Journal of atherosclerosis and thrombosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Are aortic biomechanical properties early markers of dilatation in patients with Marfan syndrome? A systematic review and meta-analysis.Biomechanics and modeling in mechanobiology · 2024Pooled it
- Cerebrovascular pulsatility following long duration spaceflight is associated with changes in pulse pressure and carotid artery stiffness.Experimental physiology · 2026Article
- Endothelial Dysfunction and Obesity: New Diagnostic and Therapeutic Strategies.International journal of molecular sciences · 2026Review
- Low-frequency resistance training enhances 2D strain-derived carotid strain and strain rate: a novel longitudinal application of strain imaging in healthy middle-aged females.European journal of applied physiology · 2026Article
- Automated Extraction of Pulsatile Stiffness and Wall Asymmetry from Aortic M-Mode Ultrasound Images.Bioengineering (Basel, Switzerland) · 2026Article
- Relationship of arterial stiffness value with hemodynamic parameters in patients undergoing cardiac surgery.Turk gogus kalp damar cerrahisi dergisi · 2026Article
- Bioadhesive and conformable bioelectronic interfaces for vasomotoricity monitoring and regulation.Nature communications · 2025Article
- Alteration in Carotid Arterial Stiffness During Passive Leg Raising May Reflect Vascular Endothelial Function.Circulation reports · 2025Article
- Shear Wave Elastography for Carotid Artery Stiffness: Ready for Prime Time?Diagnostics (Basel, Switzerland) · 2025Review
- Phonocardiography based pulse wave velocity system for non-occlusive assessment of arterial stiffness.Frontiers in cardiovascular medicine · 2025Article
- Brachial-Ankle Pulse Wave Velocity Reflects Regional Arterial Stiffness and Distensibility in Patients with Abdominal Aortic Aneurysm.Annals of vascular diseases · 2025Article
- Review
- Load-dependent mechanisms contribute to increased aortic stiffness among women with a history of preeclampsia: relation with cardiovagal baroreflex sensitivity.American journal of physiology. Heart and circulatory physiology · 2024Article
- Hemodynamics with mechanical circulatory support devices using a cardiogenic shock model.Scientific reports · 2024Article
- Arterial Stiffness and Heart Failure With Preserved Ejection Fraction.Journal of Korean medical science · 2024Review
- Endothelial Dysfunction in Obesity and Therapeutic Targets.Advances in experimental medicine and biology · 2024Review
- Arterial Stiffness as a Surrogate Marker of Cardiovascular Disease and Atherosclerosis in Patients with Vasculitides: A Literature Review.Diagnostics (Basel, Switzerland) · 2023Review
- Increasing Soluble P-Selectin Levels Predict Higher Peripheral Atherosclerotic Plaque Progression.Journal of clinical medicine · 2023Article
- Subjects Conceived through Assisted Reproductive Technologies Display Normal Arterial Stiffness.Diagnostics (Basel, Switzerland) · 2022Article
- From Cultured Vascular Cells to Vessels: The Cellular and Molecular Basis of Vascular Dysfunction in Space.Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerosis comprises two components, atherosis and sclerosis, characterized by morphological wall thickening and functional stiffening, respectively, of the arterial wall. In recent years, much interest has been directed to the role of functional changes in large arteries, i.e., increased stiffness or decreased elasticity, on the development of cardiovascular diseases. In fact, the clinical evaluation of arterial stiffness is increasingly performed in patients with cardiovascular risk factors. Local arterial stiffness is measured using an ultrasound technique implemented with an echo-tracking system at the common carotid and femoral arteries. Several indices of local arterial stiffness are obtained by ultrasound, among which stiffness parameter β is unique because it is the least affected by blood pressure at the time of measurement. Evidence from cross-sectional studies indicates that increased stiffness parameter β is associated with a number of cardiovascular risk factors, such as older age, smoking, insufficient physical activity, hypertension, obesity, metabolic syndrome, insulin resistance, type 2 diabetes, chronic kidney disease, and comorbid cardiovascular disease. Results from several prospective observational studies also suggest that carotid stiffness parameter β is a useful surrogate marker of cardiovascular events and/or mortality, although the results differ depending on the characteristics of the study subjects. Furthermore, several interventional studies have shown that carotid stiffness parameter β improved after lifestyle modification or drug treatment. In this review, we summarize the current evidence of stiffness parameter β of the carotid artery and discuss its clinical implications as a marker of vascular health or as a predictor of cardiovascular outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.