Evidence map›Paper›PMID 33583820›Full record

ArticleAnatolian journal of cardiology2021

Genetic variants associated with atrial fibrillationand long-term recurrence after catheter ablation for atrialfibrillation in Turkish patients.

Taner Ulus, Muhammet Dural, Pelin Meşe, Furkan Yetmiş, Kadir Uğur Mert, Bülent Görenek, Oğuz Çilingir, Ebru Erzurumluoglu Gökalp, Serap Arslan, Sevilhan Artan and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anatolian journal of cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Taner UlusDepartment of Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir.
Muhammet DuralDepartment of Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir.
Pelin MeşeDepartment of Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir.
Furkan YetmişDepartment of Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir.
Kadir Uğur MertDepartment of Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir.
Bülent GörenekDepartment of Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir.
Oğuz ÇilingirDepartment of Medical Genetics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir.
Ebru Erzurumluoglu GökalpDepartment of Medical Genetics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir.
Serap ArslanDepartment of Medical Genetics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir.
Sevilhan ArtanDepartment of Medical Genetics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir.
Özlem AykaçDepartment of Neurology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir.
Ertuğrul ÇolakDepartment of Biostatistics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir.
Hikmet YorgunDepartment of Cardiology, Faculty of Medicine, Hacettepe University, Ankara.
Uğur CanpolatDepartment of Cardiology, Faculty of Medicine, Hacettepe University, Ankara.
Kudret AytemirDepartment of Cardiology, Faculty of Medicine, Hacettepe University, Ankara.
Eskişehir Osmangazi University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveGenome-wide association studies have revealed that single nucleotide polymorphisms (SNPs) are associated with atrial fibrillation (AF) and can predict AF recurrence after catheter ablation in different populations. However, there exists no such data for the Turkish population. We aimed to investigate whether 11 SNPs in the PITX2, ZFHX3, EPHX2, CAV1, TBX5, TGF-1, and SCN10A were related to AF and whether these SNPs can predict long-term atrial tachyarrhythmia (ATa) recurrence after pulmonary vein isolation (PVI) for AF in Turkish patients.

methodsA total of 245 consecutive patients with non-valvular AF (44.9% men, mean age: 60.2±13.2 years, 65.3% paroxysmal AF) and 50 age- and sex-matched controls were included in this analysis. The clinical features and genetic variants were compared between the 2 groups. Of the 245 patients, 128 who underwent PVI with second-generation cryoballoon were further examined for long-term recurrence after the procedure.

resultsFour SNPs in PITX2 were significantly associated with AF (rs10033464_T: OR 3.29, 95%CI: 1.38-7.82, p=0.007; rs6838973_T: OR 3.06, 95% CI 1.36-6.87, p=0.007; rs3853445_C: OR 2.84, 95%CI: 1.27-6.36, p=0.011; rs17570669_T: OR 4.03, 95% CI: 1.71-9.51, p=0.001). Among these patients who underwent PVI, one locus in CAV1 (rs3807989_G: OR 4.50, 95% CI 1.04-19.31, p=0.043) and early recurrence (OR: 8.06, 95% CI: 2.12-30.55, p=0.002) predicted long-term AF recurrence after catheter ablation.

conclusionSignificant associations exists between 4 SNPs in PITX2 and AF (rs10033464, rs6838973, rs3853445, and rs17570669) in Turkish patients. In addition, 1 genetic variant in CAV1 (rs3807989) and early recurrence can predict long-term ATa recurrence after catheter ablation.

Indexed as

Atrial FibrillationCatheter AblationPulmonary VeinsAgedFemaleGenome-Wide Association StudyHumansMaleMiddle AgedNAV1.8 Voltage-Gated Sodium ChannelRecurrenceTreatment OutcomeNAV1.8 Voltage-Gated Sodium ChannelSCN10A protein, human

Identifiers

PMID33583820
PMCPMC8114647
OpenAlexW3119794886

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.