ArticleAnatolian journal of cardiology2021
Incidence, prognostic significance, and survival outcomes of primary cardiac sarcoma: An updated population-based retrospective study.
Article in Anatolian journal of cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 19 citations in OpenAlex.
- Multimodality treatment and survival in primary cardiac malignancies: evidence from competing-risk and machine learning analyses.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- A rare case of primary cardiac sarcoma with both intracranial metastasis and embolic infarction in a pediatric patient.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- GCE: A Framework for Interpretable Nonlinear Hazard Modeling in Cardiac Sarcoma Survival Using SEER Data.Bioengineering (Basel, Switzerland) · 2026Article
- Primary Mitral Valve Sarcoma Mimicking Infective Endocarditis.CASE (Philadelphia, Pa.) · 2026Article
- Primary Cardiac Sarcomas: Clinical Characteristics, Management, and Outcomes at a Spanish National Reference Center.Cancers · 2025Article
- Clinical characteristics and treatment outcomes of primary cardiac sarcomas: a retrospective analysis.Cardio-oncology (London, England) · 2025Article
- Article
- Giant Obstructing Left Ventricular Dedifferentiated Liposarcoma.JACC. Case reports · 2025Article
- Advancements in Diagnosis and Treatment of Cardiac Sarcomas: A Comprehensive Review.Current treatment options in oncology · 2025Review
- Case Report: Diagnostic challenges and therapeutic approaches in cardiac intimal sarcoma: a rare clinical case study.Frontiers in cardiovascular medicine · 2025Article
- Cardiac Sarcoma Mimicking Libman-Sacks Endocarditis in a Patient with Systemic Lupus Erythematosus (SLE): A Case Report and Literature Review.Journal of clinical medicine · 2024Review
- A rare presentation of primary cardiac myxofibrosarcoma: Case report and literature review.Cancer reports (Hoboken, N.J.) · 2024Review
- Surgical resection of primary intracardiac sarcomas and outcomes: A review of case reports over 20 years.Indian journal of thoracic and cardiovascular surgery · 2024Review
- Case report: Characteristics and nature of primary cardiac synovial sarcoma.Frontiers in oncology · 2024Article
- Case Report: Two cases of advanced primary cardiac angiosarcoma treated with anlotinib and a retrospective analysis of the literature.Frontiers in cardiovascular medicine · 2024Article
- Postoperative radiotherapy for high-grade primary cardiac spindle cell sarcoma: a rare entity.BMJ case reports · 2023Article
- Primary Cardiac Sarcoma: Clinical Characteristics and Prognostic Factors over the Past 2 Decades.Diseases (Basel, Switzerland) · 2023Article
- The Syncopal Sarcoma: A Rare Case of Primary Cardiac Synovial Sarcoma.JACC. Case reports · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePrimary cardiac sarcoma, a rare tumor with an aggressive course and imprecise prognosis, constitutes over 95% of all malignant cardiac tumors. Given the sparsely available evidence, there is a paucity of information regarding current knowledge on cardiac sarcoma. This study aimed to determine the incidence and incidence-based rates, patient characteristics, treatment modalities, and survival factors of cardiac sarcoma.
methodsA retrospective analysis of the incidence, incidence-based mortality rates and characteristics of cardiac sarcoma between 1975 and 2016 was carried out using the Surveillance, Epidemiology, and End Results (SEER) database. The National Cancer Institute's Joinpoint Regression program was used to calculate the Annual Percentage Changes (APC). Univariate and multivariate regression analysis were used to determine the survival characteristics.
resultsA total 408 patients were identified for the incidence analysis, while 385 eligible patients were identified for the survival analysis. The mean age at diagnosis was 46.3±17.9 years. The incidence rate (per 100.000 per year) of cardiac sarcoma within the indicated years was 0.22, with an increased APC of 1.7 (p=0.013, 95% CI=0.5-2.9). A total of 251 (61.5%) patients underwent surgery, 93 (22.8%) patients received adjuvant radiotherapy, and 197 (50.2%) patients received chemotherapy. Surgical resection, chemotherapy, stage of tumor, and younger age significantly improved the survival outcomes (p<0.001).
conclusionCardiac sarcoma is a rare type of soft tissue sarcomas with poor prognosis. Over the past 30 years, the incidence of cardiac sar-coma has been on the increase. Surgery remains the mainstay of management. Further studies are needed to compare different diagnostic and treatment modalities so as to ascertain the best treatment option that would enhance survival and prognosis of cardiac sarcoma.
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