Evidence map›Paper›PMID 33583202›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Treatment of Primary Aldosteronism Increases Plasma Epoxyeicosatrienoic Acids.

James M Luther, Dawei S Wei, Kakali Ghoshal, Dungeng Peng, Gail K Adler, Adina F Turcu, Hui Nian, Chang Yu, Carmen C Solorzano, Ambra Pozzi and 1 more

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02362308 (Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02362308 completednot on this map

Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas

TypeobservationalSponsorVanderbilt UniversityRan2015 to 2020Enrolled10ConditionsPrimary AldosteronismArmsAdrenalectomy, mineralocorticoid receptor antagonist
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Salt-Sensitive Hypertension in GRInternational journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

James M LutherFrom the Division of Clinical Pharmacology (J.M.L., D.S.W., D.P., N.J.B.), Vanderbilt University Medical Center.
Dawei S WeiFrom the Division of Clinical Pharmacology (J.M.L., D.S.W., D.P., N.J.B.), Vanderbilt University Medical Center.
Kakali GhoshalDivision of Nephrology and Hypertension (K.G., A.P.), Vanderbilt University Medical Center.
Dungeng PengFrom the Division of Clinical Pharmacology (J.M.L., D.S.W., D.P., N.J.B.), Vanderbilt University Medical Center.
Gail K AdlerDivision of Endocrinology and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School (G.K.A.).
Adina F TurcuDivision of Endocrinology, Department of Medicine, University of Michigan (A.F.T.).
Hui NianDepartment of Biostatistics, Vanderbilt University (H.N., C.Y.).
Chang YuDepartment of Biostatistics, Vanderbilt University (H.N., C.Y.).
Carmen C SolorzanoDepartment of Medicine and Department of Surgery (C.C.S.), Vanderbilt University Medical Center.
Ambra PozziDivision of Nephrology and Hypertension (K.G., A.P.), Vanderbilt University Medical Center.
Nancy J BrownFrom the Division of Clinical Pharmacology (J.M.L., D.S.W., D.P., N.J.B.), Vanderbilt University Medical Center.
Vanderbilt University Medical Center · USVanderbilt University · USBrigham and Women's Hospital · USUniversity of Michigan · USYale University · US

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3M
Vanderbilt O'Brien Kidney Center - Core D - Clinical and Translational CoreP30DK114809 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DE CAESTECKER, MARK P. · 2017 to 2021
$5.9M
Endogenous Aldosterone and Glucose HomeostasisR01DK096994 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LUTHER, JAMES MATTHEW · 2013 to 2017
$2.1M
Variation in Soluble Epoxide Hydrolase Activity and Human Insulin SensitivityR01DK117875 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BROWN, NANCY J., LUTHER, JAMES MATTHEW · 2018 to 2021
$1.9M
Matrix receptors in chronic kidney diseaseR01DK119212 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BORZA, CORINA MARILENA, POZZI, AMBRA · 2018 to 2022
$1.7M
Aldosterone and Diabetic Cardiovascular Disease: Research and Mentoring ProgamK24HL103845 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ADLER, GAIL KURR · 2011 to 2021
$1.6M
Aldosterone and Glucose MetabolismK23DK081662 · NIDDK · VANDERBILT UNIVERSITY · PI LUTHER, JAMES MATTHEW · 2008 to 2012
$863k
BLRD VA I01 BX000320BLRD VA I01 BX002025BLRD VA IK6 BX005240Doris Duke Charitable Foundation 2019087NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR002243NCATS NIH HHS UL1 TR002541NCRR NIH HHS UL1 RR024975NHLBI NIH HHS K24 HL103845NIDDK NIH HHS K08 DK109116NIDDK NIH HHS K23 DK081662NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK114809NIDDK NIH HHS R01 DK096994NIDDK NIH HHS R01 DK117875NIDDK NIH HHS R01 DK119212
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AdrenalectomyAldosteroneHyperaldosteronismHypertensionMineralocorticoid Receptor AntagonistsAdultAnimalsArachidonic AcidsBlood PressureEpoxide HydrolasesFemaleHumansInsulin SecretionKidneyMaleMiceAldosteroneArachidonic AcidsEpoxide HydrolasesMineralocorticoid Receptor Antagonistsaldosteroneeicosanoidshypertensioninsulin resistancemineralocorticoids

Identifiers

PMID33583202
PMCPMC8320355
OpenAlexW3132148978

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.