Evidence map›Paper›PMID 33583181›Full record

ArticleBiochemistry2021

Insights into Ubiquitin Product Release in Hydrolysis Catalyzed by the Bacterial Deubiquitinase SdeA.

Michael J Sheedlo, Sebastian Kenny, Ivan S Podkorytov, Kwame Brown, Jia Ma, Shalini Iyer, Chad S Hewitt, Trent Arbough, Oleg Mikhailovskii, Daniel P Flaherty and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Cocrystallization of ubiquitin-deubiquitinase complexes through disulfide linkage.Acta crystallographica. Section D, Structural biology · 2023
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Michael J SheedloDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Sebastian KennyDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Ivan S PodkorytovLaboratory of Biomolecular NMR, St. Petersburg State University, St. Petersburg 199034, Russia.
Kwame BrownDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Jia MaBindley Bioscience Center, West Lafayette, Indiana 47906, United States.
Shalini IyerDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Chad S HewittDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47906, United States.
Trent ArboughDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Oleg MikhailovskiiDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Daniel P FlahertyDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47906, United States.ORCID 0000-0002-8305-0606
Mark A WilsonDepartment of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, Nebraska 68588, United States.ORCID 0000-0001-6317-900X
Nikolai R SkrynnikovDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-7097-9192
Chittaranjan DasDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-0567-7753
Purdue University West Lafayette · USSt Petersburg University · RUUniversity of Nebraska–Lincoln · US

Funding

Mechanism of atypical ubiquitination and deubiquitination by bacterial effectorsR01GM126296 · NIGMS · PURDUE UNIVERSITY · PI Chittaranjan Das · 2018 to 2026
$3.6M
Purdue University Molecular Biophysics Training ProgramT32GM132024 · NIGMS · PURDUE UNIVERSITY · PI Angeline Marie Lyon, John Tesmer · 2019 to 2026
$2.0M
NIGMS NIH HHS R01 GM126296NIGMS NIH HHS T32 GM132024
6 · The paper itself

Abstract

We report the co-crystal structure of the (catalytic Cys)-to-Ala mutant of the deubiquitinase domain of the

Indexed as

Bacterial ProteinsCatalysisCrystallography, X-RayHydrolysisLegionella pneumophilaMembrane ProteinsModels, MolecularProtein ConformationUbiquitinationUbiquitinsBacterial ProteinsMembrane ProteinsSdeA protein, Legionella pneumophilaUbiquitins

Identifiers

PMID33583181
PMCPMC8607817
OpenAlexW3131218257

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.