Evidence map›Paper›PMID 33583155›Full record

ReviewJournal of biomedical optics2021

Terahertz radiation and the skin: a review.

Angelina I Nikitkina, Polina Y Bikmulina, Elvira R Gafarova, Nastasia V Kosheleva, Yuri M Efremov, Evgeny A Bezrukov, Denis V Butnaru, Irina N Dolganova, Nikita V Chernomyrdin, Olga P Cherkasova and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of biomedical optics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 153 citations in OpenAlex.

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  9. Quantitative imaging of individual bacterial cells:Journal of biomedical optics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Angelina I NikitkinaSechenov University, Institute for Regenerative Medicine, Moscow, Russia.
Polina Y BikmulinaSechenov University, Institute for Regenerative Medicine, Moscow, Russia.
Elvira R GafarovaSechenov University, Institute for Regenerative Medicine, Moscow, Russia.
Nastasia V KoshelevaSechenov University, Institute for Regenerative Medicine, Moscow, Russia.
Yuri M EfremovSechenov University, Institute for Regenerative Medicine, Moscow, Russia.
Evgeny A BezrukovSechenov University, Institute for Urology and Reproductive Health, Moscow, Russia.
Denis V ButnaruSechenov University, Institute for Urology and Reproductive Health, Moscow, Russia.
Irina N DolganovaSechenov University, Institute for Regenerative Medicine, Moscow, Russia.
Nikita V ChernomyrdinSechenov University, Institute for Regenerative Medicine, Moscow, Russia.
Olga P CherkasovaRussian Academy of Sciences, Institute of Laser Physics of the Siberian Branch, Novosibirsk, Russia.
Arsenii A GavdushRussian Academy of Sciences, Prokhorov General Physics Institute, Moscow, Russia.
Peter S TimashevSechenov University, Institute for Regenerative Medicine, Moscow, Russia.
Sechenov University · RUCalifornia Institute for Regenerative Medicine · USProkhorov General Physics Institute · RUInstitute of Laser Physics · RUSemenov Institute of Chemical Physics · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

significanceTerahertz (THz) radiation has demonstrated a great potential in biomedical applications over the past three decades, mainly due to its non-invasive and label-free nature. Among all biological specimens, skin tissue is an optimal sample for the application of THz-based methods because it allows for overcoming some intrinsic limitations of the technique, such as a small penetration depth (0.1 to 0.3 mm for the skin, on average).

aimWe summarize the modern research results achieved when THz technology was applied to the skin, considering applications in both imaging/detection and treatment/modulation of the skin constituents. APPROACH: We perform a review of literature and analyze the recent research achievements in THz applications for skin diagnosis and investigation.

resultsThe reviewed results demonstrate the possibilities of THz spectroscopy and imaging, both pulsed and continuous, for diagnosis of skin melanoma and non-melanoma cancer, dysplasia, scars, and diabetic condition, mainly based on the analysis of THz optical properties. The possibility of modulating cell activity and treatment of various diseases by THz-wave exposure is shown as well.

conclusionsThe rapid development of THz technologies and the obtained research results for skin tissue highlight the potential of THz waves as a research and therapeutic instrument. The perspectives on the use of THz radiation are related to both non-invasive diagnostics and stimulation and control of different processes in a living skin tissue for regeneration and cancer treatment.

Indexed as

MelanomaSkin NeoplasmsTerahertz SpectroscopyHumansSkinTerahertz Radiationcancer detection and treatmentregenerative medicineskinterahertz spectroscopy and imagingterahertz technology

Identifiers

PMID33583155
PMCPMC7881098
OpenAlexW3132538708

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.