ArticleJournal of biomedical optics2021
Estimation of skin microcirculatory hemoglobin oxygen saturation and red blood cell tissue fraction using a multispectral snapshot imaging system: a validation study.
Article in Journal of biomedical optics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 17 citations in OpenAlex.
- Learning to simulate realistic human diffuse reflectance spectra.Journal of biomedical optics · 2026Article
- Development and clinical validation of a clinically translatable non-chip-on-tip transvaginal imaging system (GynoSight v2.0) for early detection of premalignant cervical lesions.Journal of biomedical optics · 2025Article
- Artificial neural networks trained on simulated multispectral data for real-time imaging of skin microcirculatory blood oxygen saturation.Journal of biomedical optics · 2024Article
- Absorption and reduced scattering coefficients in epidermis and dermis from a Swedish cohort study.Journal of biomedical optics · 2023Article
- In vivo dose-response analysis to acetylcholine: pharmacodynamic assessment by polarized reflectance spectroscopy.Scientific reports · 2022Article
- Multispectral snapshot imaging of skin microcirculatory hemoglobin oxygen saturation using artificial neural networks trained on in vivo data.Journal of biomedical optics · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
significanceHemoglobin oxygen saturation and red blood cell (RBC) tissue fraction are important parameters when assessing microvascular status. Functional information can be attained using temporally resolved measurements performed during stimulus-response protocols. Pointwise assessments can currently be conducted with probe-based systems. However, snapshot multispectral imaging (MSI) can be used for spatial-temporal measurements.
aimTo validate if hemoglobin oxygen saturation and RBC tissue fraction can be quantified using a snapshot MSI system and an inverse Monte Carlo algorithm. APPROACH: Skin tissue measurements from the MSI system were compared to those from a validated probe-based system during arterial and venous occlusion provocation on 24 subjects in the wavelength interval 450 to 650 nm, to evaluate a wide range of hemoglobin oxygen saturation and RBC tissue fraction levels.
resultsArterial occlusion results show a mean linear regression R2 = 0.958 for hemoglobin oxygen saturation. Comparing relative RBC tissue fraction during venous occlusion results in R2 = 0.925. The MSI system shows larger dynamic changes than the reference system, which might be explained by a deeper sampling including more capacitance vessels.
conclusionsThe snapshot MSI system estimates hemoglobin oxygen saturation and RBC tissue fraction in skin microcirculation showing a high correlation (R2 > 0.9 in most subjects) with those measured by the reference method.
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