ArticleMedical physics2021
Dosimetric evaluation of MRI-guided multi-leaf collimator tracking and trailing for lung stereotactic body radiation therapy.
Article in Medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Real-time tumor tracking for magnetic resonance-guided radiotherapy using label-efficient foundation model adaptation.Physics and imaging in radiation oncology · 2026Article
- Motion mitigation in positron-emission tomography guided radiotherapy delivered on a magnetic resonance imaging-linear accelerator.Physics and imaging in radiation oncology · 2026Article
- Real-time dose reconstruction and dose coverage forecasting using the magnetic resonance linear accelerator.Physics and imaging in radiation oncology · 2026Article
- First experimental demonstration of magnetic resonance-guided multileaf collimator tracking for (ultra-)hypofractionated prostate radiotherapy.Physics and imaging in radiation oncology · 2025Article
- Application of respiratory motion management technology for patients with lung cancer treated with stereotactic body radiotherapy (Review).Oncology letters · 2025Review
- TrackRAD2025 challenge dataset: real-time tumor tracking for MRI-guided radiotherapy.Medical physics · 2025Article
- Real-time target localization on 1.5 T magnetic resonance imaging linac orthogonal cine images using transfer learning.Physics and imaging in radiation oncology · 2025Article
- Validation of a diode-based phantom for high temporal and spatial measurements in a 1.5 T MR-linac.Journal of applied clinical medical physics · 2025Article
- Recent technical advancements and clinical applications of MR-guided radiotherapy in lung cancer treatment.Frontiers in oncology · 2025Review
- Demonstration of motion-compensated volumetric modulated arc radiotherapy on an MR-linac.Physics and imaging in radiation oncology · 2025Article
- Modeling of artificial intelligence-based respiratory motion prediction in MRI-guided radiotherapy: a review.Radiation oncology (London, England) · 2024Review
- Explicitly encoding the cyclic nature of breathing signal allows for accurate breathing motion prediction in radiotherapy with minimal training data.Physics and imaging in radiation oncology · 2024Article
- Stereotactic body radiotherapy of central lung tumours using a 1.5 T MR-linac: First clinical experiences.Clinical and translational radiation oncology · 2024Article
- Influence of magnetic field on a novel scintillation dosimeter in a 1.5 T MR-linac.Journal of applied clinical medical physics · 2024Article
- Review
- Radiation Dosimetry by Use of Radiosensitive Hydrogels and Polymers: Mechanisms, State-of-the-Art and Perspective from 3D to 4D.Gels (Basel, Switzerland) · 2022Review
- A hybrid 2D/4D-MRI methodology using simultaneous multislice imaging for radiotherapy guidance.Medical physics · 2022Article
- Towards mid-position based Stereotactic Body Radiation Therapy using online magnetic resonance imaging guidance for central lung tumours.Physics and imaging in radiation oncology · 2022Article
- Intrafraction motion during radiotherapy of breast tumor, breast tumor bed, and individual axillary lymph nodes on cine magnetic resonance imaging.Physics and imaging in radiation oncology · 2022Article
- Evaluating differences in respiratory motion estimates during radiotherapy: a single planning 4DMRI versus daily 4DMRI.Radiation oncology (London, England) · 2021Article
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Authors and funding
6 authors.
Funding
Abstract
purposeThe treatment margins for lung stereotactic body radiotherapy (SBRT) are often large to cover the tumor excursions resulting from respiration, such that underdosage of the tumor can be avoided. Magnetic resonance imaging (MRI)-guided multi-leaf collimator (MLC) tracking can potentially reduce the influence of respiration to allow for smaller treatment margins. However, tracking is accompanied by system latency that may induce residual tracking errors. Alternatively, a simpler mid-position delivery combined with trailing can be used. Trailing reduces influences of respiration by compensating for baseline motion, to potentially improve target coverage. In this study, we aim to show the feasibility of MRI-guided tracking and trailing to reduce influences of respiration during lung SBRT.
methodsWe implemented MRI-guided tracking on the MR-linac using an Elekta research tracking interface to track tumor motion during intensity modulated radiotherapy (IMRT). A Quasar
resultsThe prediction filter gain was on average 25% when trained on multiple traces and 44% when trained on a single trace. The filter reduced system latency from 313 ± 2 ms to 0 ± 5 ms for 4 Hz imaging and from 215 ± 3 ms to 3 ± 3 ms for 8 Hz. The local gamma analysis for the central delivery showed that tracking improved the gamma pass-rate from 23% to 96% for periodic motion and from 14% to 93% when baseline drift was applied. For the peripheral delivery during periodic motion, delivery pass-rates improved from 22% to 93%. Comparing mid-position delivery to trailing for periodic+drift motion increased the local gamma pass rate from 15% to 98% for a central delivery and from 8% to 98% for a peripheral delivery. Furthermore, the DAHs revealed a relative
conclusionsWe provided a first experimental demonstration of the technical feasibility of MRI-guided MLC tracking and trailing for central and peripheral lung SBRT. Tracking maximizes the sparing of healthy tissue, while trailing is highly effective in mitigating baseline motion.
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