ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2021
Health-related quality of life and its predictors among adults living with HIV/AIDS and receiving antiretroviral therapy in Pakistan.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- An international compendium of health state utilities in people with HIV: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Pooled it
- Health-Related Quality of Life in People with Advanced HIV Disease, from 1996 to 2021: Systematic Review and Meta-analysis.AIDS and behavior · 2024Pooled it
- Cost-Effectiveness of Anti-retroviral Adherence Interventions for People Living with HIV: A Systematic Review of Decision Analytical Models.Applied health economics and health policy · 2023Pooled it
- Ageing with HIV: Medicine Optimisation Challenges and Support Needs for Older People Living with HIV: A Systematic Review.Drugs & aging · 2023Pooled it
- The impact of clinical pharmacist services on patient health outcomes in Pakistan: a systematic review.BMC health services research · 2021Pooled it
- Cost Considerations for Rapid Start Implementation: Analysis from Seven Rapid Start Provider Sites.AIDS and behavior · 2026Article
- Feasibility and Preferences to Adopt mHealth-Based Interventions for HIV Prevention Among High-Risk Groups: Cross-Sectional Study.JMIR human factors · 2026Article
- Evaluating the relationship between adherence to antiretroviral therapy and health-related quality of life among people living with HIV/AIDS in Northwestern Nigeria.BMC public health · 2026Article
- Correlates of quality of life in people living with HIV infection beyond viral load suppression in Africa: a scoping review.BMJ public health · 2026Article
- Quality of life, depression and sexual function in men living with HIV under effective antiretroviral therapy compared with healthy controls.Patient related outcome measures · 2026Article
- What are the key targets to improve quality of life among MSM living with HIV on antiretroviral therapy? A network analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- The rural-urban disparity in the quality of life among people living with HIV under different household structures in China: a cross-sectional study.Scientific reports · 2025Article
- "Sometimes They Exclude Us because of Our Age-That's Not Right": Perceptions of HIV Cure Research Among Diverse Long-Term Survivors in the United States.AIDS research and human retroviruses · 2025Article
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- Frequency of HIV Infection Among Pregnant Women in a Tertiary Care Hospital in Islamabad, Pakistan.Cureus · 2025Article
- Article
- Validation of the HIV/AIDS-Targeted Quality of Life (HAT-QOL) for Evaluation of Health-related Quality of Life in People Living with HIV/AIDS in Brazil.AIDS and behavior · 2024Article
- The effectiveness of health-related quality of life (HRQOL) model in people with HIV: A cross sectional study.Health science reports · 2024Article
- "It's a Lot of Closets to Come Out of in This Life": Experiences of Brazilian Gay Men Living with Human Immunodeficiency Virus at the Time of Diagnosis and Its Biopsychosocial Impacts.European journal of investigation in health, psychology and education · 2024Article
- Cluster-Based Multinomial Logistic Regression Model for Health-Related Quality of Life Among People Living with HIV in Brazil.AIDS and behavior · 2024Article
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Authors and funding
10 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHealth-related quality of life (HRQoL) is considered to be the fourth 90 of UNAIDS 90-90-90 target to monitor the effects of combination antiretroviral therapy (ART). ART has significantly increased the life expectancy of people living with HIV/AIDS (PLWHA). However, the impact of chronic infection on HRQoL remains unclear, while factors influencing the HRQoL may vary from one country to another. The current study aimed to assess HRQoL and its associated factors among PLWHA receiving ART in Pakistan.
methodsA cross-sectional descriptive study was conducted among PLWHA attending an ART centre of a tertiary care hospital in Islamabad, Pakistan. HRQoL was assessed using a validated Urdu version of EuroQol 5 dimensions 3 level (EQ-5D-3L) and its Visual Analogue Scale (EQ-VAS).
resultsOf the 602 patients included in the analyses, 59.5% (n = 358) reported no impairment in self-care, while 63.1% (n = 380) were extremely anxious/depressed. The overall mean EQ-5D utility score and visual analogue scale (EQ-VAS) score were 0.388 (SD: 0.41) and 66.20 (SD: 17.22), respectively. Multivariate linear regression analysis revealed that the factors significantly associated with HRQoL were: female gender; age > 50 years; having primary and secondary education; > 1 year since HIV diagnosis; HIV serostatus AIDS-converted; higher CD 4 T lymphocytes count; detectable viral load; and increased time to ART.
conclusionsThe current findings have shown that PLWHA in Pakistan adherent to ART had a good overall HRQoL, though with significantly higher depression. Some of the factors identified are amenable to institution-based interventions while mitigating depression to enhance the HRQoL of PLWHA in Pakistan. The HRQoL determined in this study could be useful for future economic evaluation studies for ART and in designing future interventions.
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