Evidence map›Paper›PMID 33582815›Full record

ArticleSleep2021

Workshop report. Circadian rhythm sleep-wake disorders: gaps and opportunities.

Jeanne F Duffy, Sabra M Abbott, Helen J Burgess, Stephanie J Crowley, Jonathan S Emens, Lawrence J Epstein, Karen L Gamble, Brant P Hasler, David A Kristo, Roneil G Malkani and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 91 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Research priorities to improve classification of sleep-wake disorders.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Review
  7. Article
  8. Review
  9. The relationship between sleep and circadian-sleep phase angles based on dim light melatonin onset predicted from light and activity data.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  10. Review
  11. Article
  12. Pathophysiological Models of Hypersomnolence Associated With Depression.Biological psychiatry global open science · 2025
    Review
  13. Article
  14. Review
  15. [Effects of Extreme Environments on Human Sleep].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Review
  16. Article
  17. Managing non-24-hour sleep-wake rhythm disorder with ramelteon in a 12-year-old girl with Pierre Robin sequence and developmental delay: a case report.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Jeanne F DuffyDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.ORCID 0000-0003-4177-4179
Sabra M AbbottDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0002-8947-9649
Helen J BurgessDepartment of Psychiatry, University of Michigan, Ann Arbor, MI.ORCID 0000-0003-3816-8194
Stephanie J CrowleyDepartment of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL.ORCID 0000-0003-2057-9876
Jonathan S EmensDepartment of Psychiatry, Oregon Health & Science University, Portland, OR.
Lawrence J EpsteinDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Karen L GambleDepartment of Psychiatry University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0003-3813-8577
Brant P HaslerDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.
David A KristoDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Roneil G MalkaniDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Shadab A RahmanDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.ORCID 0000-0002-8729-0500
S Justin ThomasDepartment of Psychiatry University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0002-8709-4083
James K WyattDepartment of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL.ORCID 0000-0001-6454-1736
Phyllis C ZeeDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Elizabeth B KlermanDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.ORCID 0000-0002-7402-3171
Brigham and Women's Hospital · USNorthwestern University · USRush University Medical Center · USUniversity of Alabama at Birmingham · USUniversity of Pittsburgh · USOregon Health & Science University · USUniversity of Michigan · US

Funding

SLOW WAVE SLEEP AND TYPE 2 DIABETES RISK IN AGINGP01AG011412 · NIA · UNIVERSITY OF CHICAGO · PI ZEE, PHYLLIS C. · 1994 to 2021
$31.5M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Treatment of Circadian Disruption from Shiftwork in Older AdultsR01AG044416 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI DUFFY, JEANNE F · 2013 to 2022
$4.3M
Strengthening circadian signals to enhance cardiometabolic functionR01HL140580 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ZEE, PHYLLIS C. · 2017 to 2021
$3.4M
Delayed sleep phase and risk for adolescent substance useR01DA044143 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HASLER, BRANT P. · 2018 to 2022
$2.8M
Sleep Duration Required to Restore Performance during Chronic Sleep RestrictionK24HL105664 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI KLERMAN, ELIZABETH B. · 2010 to 2019
$1.8M
NHLBI NIH HHS K24 HL105664NHLBI NIH HHS R01 HL140580NIA NIH HHS P01 AG011412NIA NIH HHS R01 AG044416NIDA NIH HHS R01 DA044143NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

This White Paper presents the results from a workshop cosponsored by the Sleep Research Society (SRS) and the Society for Research on Biological Rhythms (SRBR) whose goals were to bring together sleep clinicians and sleep and circadian rhythm researchers to identify existing gaps in diagnosis and treatment and areas of high-priority research in circadian rhythm sleep-wake disorders (CRSWD). CRSWD are a distinct class of sleep disorders caused by alterations of the circadian time-keeping system, its entrainment mechanisms, or a misalignment of the endogenous circadian rhythm and the external environment. In these disorders, the timing of the primary sleep episode is either earlier or later than desired, irregular from day-to-day, and/or sleep occurs at the wrong circadian time. While there are incomplete and insufficient prevalence data, CRSWD likely affect at least 800,000 and perhaps as many as 3 million individuals in the United States, and if Shift Work Disorder and Jet Lag are included, then many millions more are impacted. The SRS Advocacy Taskforce has identified CRSWD as a class of sleep disorders for which additional high-quality research could have a significant impact to improve patient care. Participants were selected for their expertise and were assigned to one of three working groups: Phase Disorders, Entrainment Disorders, and Other. Each working group presented a summary of the current state of the science for their specific CRSWD area, followed by discussion from all participants. The outcome of those presentations and discussions are presented here.

Indexed as

MelatoninSleep Disorders, Circadian RhythmSleep Wake DisordersCircadian RhythmHumansJet Lag SyndromeSleepMelatoninactigraphyadvanced sleep–wake phase disorderbright light therapychronotypecircadian amplitudecircadian periodcircadian phasecircadian rhythm sleep–wake disordersdelayed sleep–wake phase disorderdim light melatonin onsetentrainmentirregular sleep–wake rhythm disordermelatoninnon-24-hour sleep–wake disorder

Identifiers

PMID33582815
PMCPMC8120340
OpenAlexW3131018607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.