Evidence map›Paper›PMID 33582601›Full record

ArticleThrombosis research2021

Racial differences in platelet serotonin polymorphisms in acute coronary syndrome.

Marlene S Williams, Lisa Yanek, Roy C Ziegelstein, Una McCann, Nauder Faraday

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thrombosis research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Marlene S WilliamsDivision of Cardiology, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, MD 21224, United States of America. Electronic address: mwillia1@jhmi.edu.
Lisa YanekDivision of Cardiology, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, MD 21224, United States of America.
Roy C ZiegelsteinDivision of Cardiology, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, MD 21224, United States of America.
Una McCannDepartment of Psychiatry, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, MD 21224, United States of America.
Nauder FaradayDepartment of Anesthesia, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, MD 21224, United States of America.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

Mechanisms of Platelet Activation in Depression and Acute Coronary SyndromesR01HL096694 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WILLIAMS, MARLENE S · 2010 to 2014
$2.0M
NHLBI NIH HHS R01 HL096694
6 · The paper itself

Abstract

introductionGenetic differences between races have been hypothesized to contribute to differences in outcome from acute coronary syndromes (ACS). Our objective was to assess racial differences in genetic variations in the platelet serotonin transporter (5HTT) and receptor in patients with ACS. MATERIALS AND

methods127 consecutive patients, African Americans (AA) = 27; Caucasian (C) =100, admitted with ACS were evaluated for platelet function by serotonin (5HT) induced platelet activation. All patients were genotyped for two polymorphisms in the serotonin-transporter-linked polymorphic region (5-HTTLPR) S/L and L

resultsAA when compared to C had a lower prevalence of the HTTLPR S allele (21% vs 45%, p = 0.0003) and a higher prevalence of the L

conclusionWe found a lower prevalence of the S allele and a higher prevalence of the G allele in AA with ACS. We also found decreased platelet activation in AA which did not correlate with serotonin-related platelet polymorphisms. It is unclear if other contributing factors may explain these platelet functional differences.

Indexed as

Acute Coronary SyndromeSerotoninGenotypeHumansPolymorphism, GeneticRace FactorsSerotonin Plasma Membrane Transport ProteinsSerotoninSerotonin Plasma Membrane Transport ProteinsCoronary diseasePlatelet functionPlatelet polymorphismRaceSerotonin

Identifiers

PMID33582601
PMCPMC8026585
OpenAlexW3127803946

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.