Evidence map›Paper›PMID 33582223›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2021

A Developmental Pathway From Early Behavioral Inhibition to Young Adults' Anxiety During the COVID-19 Pandemic.

Selin Zeytinoglu, Santiago Morales, Nicole E Lorenzo, Andrea Chronis-Tuscano, Kathryn A Degnan, Alisa N Almas, Heather Henderson, Daniel S Pine, Nathan A Fox

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05582512 (Clinical Characteristics and Long Term Impact on Pediatric COVID-19 in Taiwan), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05582512 recruitingnot on this mapstarted 2022, after this paper: background citation

Clinical Characteristics and Long Term Impact on Pediatric COVID-19 in Taiwan

Typeobservational_patient_registrySponsorNational Taiwan University HospitalRan2022 to 2027Enrolled3,000ConditionsLong Covid19, COVID-19 Pneumonia, Multisystem Inflammatory Syndrome in ChildrenArmssequelae tracking
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. A Developmental Pathway from Early Inhibitory Control to Social Connectedness.Research on child and adolescent psychopathology · 2023
    Article
  9. Which Anxious Adolescents Were Most Affected by the COVID-19 Pandemic?Clinical psychological science : a journal of the Association for Psychological Science · 2022
    Article
  10. Review
  11. Article
  12. Tools to Address Children's Mental Health.Focus (American Psychiatric Publishing) · 2022
    Article
  13. Pathways from maternal shyness to adolescent social anxiety.Journal of child psychology and psychiatry, and allied disciplines · 2022
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. When the World Pivots: Changes in Infant Negative Affect Trajectories Following the Onset of the COVID-19 Pandemic.Infancy : the official journal of the International Society on Infant Studies
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Selin ZeytinogluUniversity of Maryland, College Park. Electronic address: selin@umd.edu.
Santiago MoralesUniversity of Maryland, College Park.
Nicole E LorenzoUniversity of Maryland, College Park.
Andrea Chronis-TuscanoUniversity of Maryland, College Park.
Kathryn A DegnanThe Catholic University of America, Washington, DC.
Alisa N AlmasUniversity of British Columbia, Vancouver.
Heather HendersonUniversity of Waterloo, Ontario.
Daniel S PineNational Institute of Mental Health, Bethesda, Maryland.
Nathan A FoxUniversity of Maryland, College Park.
University of Maryland, College Park · USNational Institute of Mental Health · USUniversity of America · USUniversity of British Columbia · CAUniversity of Waterloo · CA

Funding

Fmri Studies Of Risk For Mood And Anxiety Disorders In ChildrenZIAMH002782 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$28.3M
Trajectories of Behavioral Inibition and Risk for AnxietyU01MH093349 · NIMH · UNIV OF MARYLAND, COLLEGE PARK · PI FOX, NATHAN A · 2011 to 2020
$6.6M
Affect &Cerebral Asymmetry: A Developmental ApproachR37HD017899 · NICHD · UNIV OF MARYLAND, COLLEGE PARK · PI FOX, NATHAN A · 2001 to 2010
$5.6M
2/2 Treating Mothers with ADHD and their Young Children Via Telehealth: A Hybrid Type I Effectiveness-Implementation TrialR01MH118320 · NIMH · UNIV OF MARYLAND, COLLEGE PARK · PI CHRONIS-TUSCANO, ANDREA · 2019 to 2023
$4.1M
AFFECT AND CEREBRAL ASYMMETRY: A DEVELOPMENTAL APPROACHR01HD017899 · NICHD · UNIVERSITY OF MARYLAND COLLEGE PK CAMPUS · PI FOX, NATHAN A · 1985 to 2000
$284k
Intramural NIH HHS ZIA MH002782NICHD NIH HHS R01 HD017899NICHD NIH HHS R37 HD017899NIMH NIH HHS R01 MH118320NIMH NIH HHS U01 MH093349
6 · The paper itself

Abstract

objectiveThe COVID-19 pandemic has brought unprecedented changes to young adults' lives, resulting in mental health difficulties for many; however, some individuals are particularly prone to heightened anxiety. Little is known about the early life predictors of anxiety during the pandemic. We examined a developmental pathway from behavioral inhibition (BI), a temperament characterized by fearful responses toward novelty, to changes in young adults' anxiety during the initial period of the pandemic. We hypothesized that a stable pattern of BI across early childhood would predict greater adolescent worry dysregulation, which in turn would predict increases in young adult anxiety during a stressful phase of the pandemic.

methodParticipants (N = 291; 54% female) were followed from toddlerhood to young adulthood. BI was observed at ages 2 and 3 years. Social wariness was observed at age 7 years. Participants rated their worry dysregulation in adolescence (age 15) and anxiety in young adulthood (age 18) at 2 assessments during the COVID-19 pandemic, 1 month apart.

resultsA significant moderated mediation, in which a stable pattern of BI from toddlerhood to childhood, as compared to the absence of this pattern, predicted greater worry dysregulation in adolescence. Worry dysregulation predicted elevated young adult anxiety in the second assessment during COVID-19, even after accounting for the first assessment.

conclusionThis study identifies a developmental pathway from toddlerhood BI to young adults' elevated anxiety during the COVID-19 pandemic. Findings have implications for early identification of individuals at risk for dysregulated worry and the prevention of anxiety during stressful life events in young adulthood.

Indexed as

COVID-19PandemicsAdolescentAdultAnxietyChildChild, PreschoolFemaleHumansInhibition, PsychologicalMaleSARS-CoV-2Young Adultanxietybehavioral inhibitionCOVID-19 pandemictemperamentworry

Identifiers

PMID33582223
PMCPMC8357851
OpenAlexW3131767661

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.