Evidence map›Paper›PMID 33582151›Full record

ArticleNeuropharmacology2021

The contribution of medium spiny neuron subtypes in the nucleus accumbens core to compulsive-like ethanol drinking.

Elizabeth A Sneddon, Kristen M Schuh, John W Frankel, Anna K Radke

Open access · greenAbstract read
In one paragraph

Article in Neuropharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 26 citations in OpenAlex.

  1. Alcohol Cues Invigorate Aversion-Resistant Alcohol Drinking.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. A Drd1-cre mouse line with nucleus accumbens gene dysregulation exhibits blunted fentanyl seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  4. Article
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  7. Animal Models of Excessive Alcohol Consumption in Rodents.Current topics in behavioral neurosciences · 2025
    Review
  8. Punishment-resistant alcohol intake is mediated by the nucleus accumbens shell in female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Elizabeth A SneddonDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Kristen M SchuhDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
John W FrankelDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Anna K RadkeDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA. Electronic address: aradke@miamioh.edu.
Miami University · US

Funding

Analysis of subcortical networks that promote aversion-resistant alcohol drinkingR15AA027915 · NIAAA · MIAMI UNIVERSITY OXFORD · PI RADKE, ANNA KAY · 2020 to 2020
$378k
Mechanisms Underlying Female Vulnerability to Compulsive Alcohol DrinkingF99NS118727 · NINDS · MIAMI UNIVERSITY OXFORD · PI SNEDDON, ELIZABETH · 2021 to 2022
$84k
NIAAA NIH HHS R15 AA027915NINDS NIH HHS F99 NS118727
6 · The paper itself

Abstract

Compulsive alcohol use, or drinking that persists despite negative or aversive consequences, is a defining characteristic of alcohol use disorder. Here, chemogenetic technology (i.e. Designer Receptors Exclusively Activated by Designer Drugs; DREADDs) was used to inhibit or excite the NAc core or selectively inhibit D

Indexed as

Alcohol DrinkingCompulsive BehaviorAlcoholismAnimalsBehavior, AnimalCentral Nervous System DepressantsDisease Models, AnimalDopaminergic NeuronsEthanolMiceNeuronsNucleus AccumbensQuinineReceptors, Dopamine D1Receptors, Dopamine D2Self AdministrationCentral Nervous System DepressantsDrd1 protein, mouseDRD2 protein, mouseEthanolQuinineReceptors, Dopamine D1Receptors, Dopamine D2AlcoholAversionDopamineDrinking in the darkNucleus accumbensReward

Identifiers

PMID33582151
PMCPMC7986485
OpenAlexW3132052013

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.