Evidence map›Paper›PMID 33582116›Full record

ReviewDevelopmental biology2021

Balancing energy expenditure and storage with growth and biosynthesis during Drosophila development.

Claire M Gillette, Jason M Tennessen, Tânia Reis

Abstract readReview
In one paragraph

Review in Developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Exposure to perfluorooctanoic acid acceleratesbioRxiv : the preprint server for biology · 2026
    Article
  3. ThebioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Biomolecules · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Regulating metabolism to shape immune function: Lessons from Drosophila.Seminars in cell & developmental biology · 2023
    Review
  18. Inositol in Disease and Development: Roles of Catabolism viaInternational journal of molecular sciences · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Claire M GilletteDepartment of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Jason M TennessenDepartment of Biology, Indiana University, Bloomington, IN, 47405, USA. Electronic address: jtenness@indiana.edu.
Tânia ReisDepartment of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. Electronic address: tania.reis@cuanschutz.edu.

Funding

A Drosophila Model for the Regulation of Aerobic GlycolysisR35GM119557 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Jason Michael Tennessen · 2016 to 2026
$4.7M
Predoctoral Training Program in Molecular and Cellular Biology (Supplement: Mentoring in the Research Environment)T32GM136444 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI MICHAEL A MCMURRAY, Rytis Prekeris · 2020 to 2026
$3.7M
Mechanisms of fat regulation by conserved anti-obesity genesR01DK106177 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI REIS, TANIA · 2017 to 2022
$2.0M
NIDDK NIH HHS R01 DK106177NIGMS NIH HHS R35 GM119557NIGMS NIH HHS T32 GM136444
6 · The paper itself

Abstract

Sustaining life requires efficient uptake of nutrients and conversion to useable forms. Almost everything about this process is dynamic. Nutrient availability fluctuates and changing environmental conditions impose new demands that can tip the metabolic equilibrium from biosynthesis and macromolecule storage to energy expenditure. At the same time, the organism itself changes, particularly during the rapid growth and differentiation in early development and also later in life as the adult ages. Here we review what has been learned from Drosophila melanogaster as an experimental model about the connections between external signals, signaling pathways, tissues and organs that allow animals to balance energy storage with expenditure in the face of change, both intrinsic and extrinsic.

Indexed as

AnimalsDrosophila melanogasterDrosophila ProteinsEnergy MetabolismHomeostasisNutrientsSignal TransductionDrosophila ProteinsNutrientsDevelopmentDrosophilaEnergy expenditureEnergy storageGrowthMetabolismNutrition

Identifiers

PMID33582116
PMCPMC8543490

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.