ArticleBiological psychiatry2021
Reduced Glutamate Turnover in the Putamen Is Linked With Automatic Habits in Human Cocaine Addiction.
Article in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Bad habits-good goals? Meta-analysis and translation of the habit construct to alcoholism.Translational psychiatry · 2024Pooled it
- [The sensorimotor domain in the research domain criteria system: progress and perspectives].Der Nervenarzt · 2021Pooled it
- Behavioral flexibility and gut microbiome as potential predictors of oral oxycodone self-administration.bioRxiv : the preprint server for biology · 2026Article
- Heroin addiction modulates transcription factor binding in regulatory regions of the human putamen.Scientific reports · 2026Article
- Inhibitory control deficits in problematic short-form video users: evidence from drift diffusion model.BMC psychology · 2026Article
- Does the Habit Theory of Addictions Extend to Disordered Gambling?Current addiction reports · 2026Review
- Relationship between elevated habituation tendencies and impulsivity, compulsivity, and childhood adversity among abstinent patients with methamphetamine use disorders.European archives of psychiatry and clinical neuroscience · 2025Article
- Increasingly dependent on habit? A study on the electrophysiological mechanisms of goal-directed and habitual control in internet gaming disorder.Journal of behavioral addictions · 2025Article
- Development and validation of the Compulsive Substance Use Questionnaire: Attending to substance use automaticity, craving, and continued use despite negative consequences.Journal of substance use and addiction treatment · 2025Article
- Goal-direction and habit in human and nonhuman behavioral sequences (behavior chains).Journal of experimental psychology. Animal learning and cognition · 2025Article
- Effects of sex and estrous cycle on action-outcome contingencies.Behavioural brain research · 2025Article
- Differential influence of habit components on compulsive and problematic reward-seeking behavior.PLOS mental health · 2025Article
- Localization and connections of the tail of caudate and caudal putamen in mouse brain.Frontiers in neural circuits · 2025Article
- Defending and defining compulsive behaviour in addiction.Addiction biology · 2024Article
- Article
- Topological features of functional brain networks and subclinical impulsivity: an investigation in younger and older adults.Brain structure & function · 2024Article
- From compulsivity to compulsion: the neural basis of compulsive disorders.Nature reviews. Neuroscience · 2024Review
- Characterizing Human Habits in the Lab.Collabra. Psychology · 2024Article
- Article
- Mesocorticolimbic function in cocaine polydrug users: A multimodal study of drug cue reactivity and cognitive regulation.Addiction biology · 2024Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe balance between goal-directed behavior and habits has been hypothesized to be biased toward the latter in individuals with cocaine use disorder (CUD), suggesting possible neurochemical changes in the putamen, which may contribute to their compulsive behavior.
methodsWe assessed habitual behavior in 48 patients with CUD and 42 healthy control participants using a contingency degradation paradigm and the Creature of Habit Scale. In a subgroup of this sample (CUD: n = 21; control participants: n = 22), we also measured glutamate and glutamine concentrations in the left putamen using ultra-high-field (7T) magnetic resonance spectroscopy. We hypothesized that increased habitual tendencies in patients with CUD would be associated with abnormal glutamatergic metabolites in the putamen.
resultsCompared with their non-drug-using peers, patients with CUD exhibited greater habitual tendencies during contingency degradation, which correlated with increased levels of self-reported daily habits. We further identified a significant reduction in glutamate concentration and glutamate turnover (glutamate-to-glutamine ratio) in the putamen in patients with CUD, which was significantly related to the level of self-reported daily habits.
conclusionsPatients with CUD exhibit enhanced habitual behavior, as assessed both by questionnaire and by a laboratory paradigm of contingency degradation. This automatic habitual tendency is related to a reduced glutamate turnover in the putamen, suggesting a dysregulation of habits caused by chronic cocaine use.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.