ArticleArthritis research & therapy2021
Detection of knee synovitis using non-contrast-enhanced qDESS compared with contrast-enhanced MRI.
Article in Arthritis research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Insights into the complex relationship between pain and imaging-detected structural damage in knee osteoarthritis.Skeletal radiology · 2026Review
- Recent evolution in imaging techniques for assessment of synovitis in osteoarthritis.Skeletal radiology · 2025Review
- Multifaceted imaging strategies for clinical trials of knee osteoarthritis-a tightly interlinked value and precision chain.Skeletal radiology · 2025Review
- Advances in molecular imaging for osteoarthritis.Connective tissue research · 2025Review
- The 18th international workshop on osteoarthritis imaging. Structure and pain: Where are we today?Osteoarthritis imaging · 2025Review
- Imaging-based measures of synovitis in knee osteoarthritis: A scoping review and narrative synthesis.Osteoarthritis and cartilage open · 2025Review
- The design of a sample rapid magnetic resonance imaging (MRI) acquisition protocol supporting assessment of multiple articular tissues and pathologies in knee osteoarthritis.Osteoarthritis and cartilage open · 2024Article
- Review of strategies to reduce the contamination of the water environment by gadolinium-based contrast agents.Insights into imaging · 2024Review
- Fluid-attenuated inversion-recovery sequence with fat suppression as an alternative to contrast-enhanced MRI in pediatric synovitis.Pediatric radiology · 2024Article
- Advanced Magnetic Resonance Imaging and Molecular Imaging of the Painful Knee.Seminars in musculoskeletal radiology · 2023Review
- Update on recent developments in imaging of inflammation in osteoarthritis: a narrative review.Skeletal radiology · 2023Review
- Imaging of early-stage osteoarthritis: the needs and challenges for diagnosis and classification.Skeletal radiology · 2023Article
- Fluid-Attenuated Inversion Recovery Sequence with Fat Suppression for Assessment of Ankle Synovitis without Contrast Enhancement: Comparison with Contrast-Enhanced MRI.Diagnostics (Basel, Switzerland) · 2023Article
- Imaging of Synovial Inflammation in Osteoarthritis, From theAJR. American journal of roentgenology · 2022Review
- To Contrast or Not to Contrast? On the Role of Contrast Enhancement in Hand MRI Studies of Patients with Rheumatoid Arthritis.Diagnostics (Basel, Switzerland) · 2022Article
- Gadolinium-free assessment of synovitis using diffusion tensor imaging.NMR in biomedicine · 2022Article
- Latest advancements in imaging techniques in OA.Therapeutic advances in musculoskeletal disease · 2022Review
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Authors and funding
9 authors at 4 institutions in 3 countries.
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Abstract
backgroundTo assess diagnostic accuracy of quantitative double-echo in steady-state (qDESS) MRI for detecting synovitis in knee osteoarthritis (OA).
methodsPatients with different degrees of radiographic knee OA were included prospectively. All underwent MRI with both qDESS and contrast-enhanced T1-weighted magnetic resonance imaging (CE-MRI). A linear combination of the two qDESS images can be used to create an image that displays contrast between synovium and the synovial fluid. Synovitis on both qDESS and CE-MRI was assessed semi-quantitatively, using a whole-knee synovitis sum score, indicating no/equivocal, mild, moderate, and severe synovitis. The correlation between sum scores of qDESS and CE-MRI (reference standard) was determined using Spearman's rank correlation coefficient and intraclass correlation coefficient for absolute agreement. Receiver operating characteristic analysis was performed to assess the diagnostic performance of qDESS for detecting different degrees of synovitis, with CE-MRI as reference standard.
resultsIn the 31 patients included, very strong correlation was found between synovitis sum scores on qDESS and CE-MRI (ρ = 0.96, p < 0.001), with high absolute agreement (0.84 (95%CI 0.14-0.95)). Mean sum score (SD) values on qDESS 5.16 (3.75) were lower than on CE-MRI 7.13 (4.66), indicating systematically underestimated synovitis severity on qDESS. For detecting mild synovitis or higher, high sensitivity and specificity were found for qDESS (1.00 (95%CI 0.80-1.00) and 0.909 (0.571-1.00), respectively). For detecting moderate synovitis or higher, sensitivity and specificity were good (0.727 (95%CI 0.393-0.927) and 1.00 (0.800-1.00), respectively).
conclusionqDESS MRI is able to, however with an underestimation, detect synovitis in patients with knee OA.
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