SynthesisJournal of Crohn's & colitis2021
Prevalence and Progression of Incidental Terminal Ileitis on Non-diagnostic Colonoscopy: A Systematic Review and Meta-analysis.
Synthesis in Journal of Crohn's & colitis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Prevalence and Clinical Features of Incidental Inflammatory Bowel Disease Identified During Screening and Surveillance Colonoscopy.Digestive diseases and sciences · 2026Article
- Terminal ileum in screening colonoscopy: routine practice or risk-stratified approach?Clinical endoscopy · 2025Article
- Local Guidelines Regarding the Therapeutic and Diagnostic Management of Silent Crohn's Patients.International journal of preventive medicine · 2025Review
- Terminal ileitis: Another Battle of Panipat or just a skirmish?Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Article
- Mild Crohn's Disease: Definition and Management.Current gastroenterology reports · 2023Review
- Etiological spectrum of isolated ileo-cecal ulcers in patients with gastrointestinal symptoms.Journal of clinical and translational research · 2023Article
- Incidentally Diagnosed Asymptomatic Crohn's Disease: A Retrospective Cohort Study of Long-Term Clinical Outcomes.Crohn's & colitis 360 · 2022Article
- Nonspecific ileitis: Impact of histopathology and gastrointestinal ultrasound in achieving the diagnosis of Crohn's disease.JGH open : an open access journal of gastroenterology and hepatology · 2022Article
- Approach to the Management of Recently Diagnosed Inflammatory Bowel Disease Patients: A User's Guide for Adult and Pediatric Gastroenterologists.Gastroenterology · 2021Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundIncidentally diagnosed terminal ileitis [IDTI] has been reported among asymptomatic persons undergoing non-diagnostic colonoscopy. The purpose of our study was to determine the prevalence and long-term outcomes of asymptomatic terminal ileitis.
methodsWe performed a systematic review using three biomedical databases [Medline, Embase, and Web of Science] and relevant scientific meeting abstracts. We identified observational studies that reported the prevalence of IDTI in adults undergoing screening or polyp surveillance colonoscopy and/or the long-term outcomes of such lesions. A random-effects meta-analysis was conducted to determine the pooled prevalence rate of IDTI. The progression of IDTI to overt Crohn's disease [CD] was also described.
resultsOf 2388 eligible studies, 1784 were screened after excluding duplicates, 84 were reviewed in full text, and 14 studies were eligible for inclusion. Seven studies reported the prevalence of IDTI in 44 398 persons undergoing non-diagnostic colonoscopy, six studies reported follow-up data, and one study reported both types of data. The pooled prevalence rate of IDTI was 1.6% (95% confidence interval [CI] 0.1-21.8%) with significant heterogeneity [I2 = 99.7]. Among patients who had undergone non-diagnostic colonoscopy and had follow-up data [range 13-84 months reported in five studies], progression to overt CD was rare.
conclusionsIDTI is not uncommon on non-diagnostic colonoscopies. Based on limited data, the rate of its progression to overt CD seems low, and watchful waiting is likely a reasonable strategy. Further long-term follow-up studies are needed to inform the natural history of incidental terminal ileitis, factors that predict progression to CD, and therapeutic implications.
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Registered trials
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