ArticleJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer2021
Lung Cancer Screening With Low Dose Computed Tomography in Patients With and Without Prior History of Cancer in the National Lung Screening Trial.
Article in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Impact of low-dose computed tomography (LDCT) screening on lung cancer-related mortality.The Cochrane database of systematic reviews · 2022Pooled it
- Lung Cancer Screening in Cancer Survivors vs Those Without a History of Cancer.JAMA network open · 2025Article
- Limited effect of antibiotic use on the management of pulmonary ground-glass nodules.Scientific reports · 2025Article
- DenseNet_ HybWWoA: A DenseNet-Based Brain Metastasis Classification with a Hybrid Metaheuristic Feature Selection Strategy.Biomedicines · 2023Article
- Deep learning-based detection algorithm for brain metastases on black blood imaging.Scientific reports · 2022Article
- Subsequent Primary Cancer Risk Among 5-Year Survivors of Adolescent and Young Adult Cancers.Journal of the National Cancer Institute · 2022Article
- European lung cancer screening: valuable trial evidence for optimal practice implementation.The British journal of radiology · 2022Article
- Development and Validation of a Risk Prediction Model for Second Primary Lung Cancer.Journal of the National Cancer Institute · 2022Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionPatients with a prior history of cancer (PHC) are at increased risk of second primary malignancy, of which lung cancer is the most common. We compared the performance metrics of positive screening rates and cancer detection rates (CDRs) among those with versus without PHC.
methodsWe conducted a secondary analysis of 26,366 National Lung Screening Trial participants screened with low dose computed tomography between August 2002 and September 2007. We evaluated absolute rates and age-adjusted relative risks (RRs) of positive screening rates on the basis of retrospective Lung CT Screening Reporting & Data System (Lung-RADS) application, invasive diagnostic procedure rate, complication rate, and CDR in those with versus without PHC using a binary logistic regression model using Firth's penalized likelihood. We also compared cancer type, stage, and treatment in those with versus without PHC.
resultsA total of 4.1% (n = 1071) of patients had PHC. Age-adjusted rates of positive findings were similar in those with versus without PHC (Baseline: PHC = 13.7% versus no PHC = 13.3%, RR [95% confidence interval (CI)]: 1.04 [0.88-1.24]; Subsequent: PHC = 5.6% versus no PHC = 5.5%, RR [95% CI]: 1.02 [0.84-1.23]). Age-adjusted CDRs were higher in those with versus without PHC on baseline (PHC=1.9% versus no PHC = 0.8%, RR [95% CI]: 2.51 [1.67-3.81]) but not on subsequent screenings (PHC = 0.6% versus no PHC = 0.4%, RR [95% CI]: 1.37 [0.99-1.93]). There were no differences in cancer stage, type, or treatment by PHC status.
conclusionsPatients with PHC may benefit from lung cancer screening, and with their providers, should be made aware of the possibility of higher cancer detection, invasive procedures, and complication rates on baseline lung cancer screening, but not on subsequent low dose computed tomography screening examinations.
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