Evidence map›Paper›PMID 33581218›Full record

ArticleBiochimica et biophysica acta. Molecular cell research2021

2-Methoxyestradiol and its derivatives inhibit store-operated Ca

Anke Löhndorf, Leon Hosang, Wolfgang Dohle, Francesca Odoardi, Sissy-Alina Waschkowski, Anette Rosche, Andreas Bauche, Riekje Winzer, Eva Tolosa, Sabine Windhorst and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Molecular cell research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Anke LöhndorfThe Ca(2+) Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany.
Leon HosangInstitute for Neuroimmunology and Multiple Sclerosis Research, University Medical Centre Göttingen, Von-Siebold-Straße 3a, D-37075 Göttingen, Germany.
Wolfgang DohleDrug Discovery & Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom.
Francesca OdoardiInstitute for Neuroimmunology and Multiple Sclerosis Research, University Medical Centre Göttingen, Von-Siebold-Straße 3a, D-37075 Göttingen, Germany.
Sissy-Alina WaschkowskiThe Ca(2+) Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany.
Anette RoscheThe Ca(2+) Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany.
Andreas BaucheThe Ca(2+) Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany.
Riekje WinzerDepartment of Immunology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany.
Eva TolosaDepartment of Immunology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany.
Sabine WindhorstDepartment of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany.
Stephen MarryInstitute for Neuroimmunology and Multiple Sclerosis Research, University Medical Centre Göttingen, Von-Siebold-Straße 3a, D-37075 Göttingen, Germany.
Alexander FlügelInstitute for Neuroimmunology and Multiple Sclerosis Research, University Medical Centre Göttingen, Von-Siebold-Straße 3a, D-37075 Göttingen, Germany.
Barry V L PotterDrug Discovery & Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom.
Björn-Philipp DiercksThe Ca(2+) Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany.
Andreas H GuseThe Ca(2+) Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany. Electronic address: guse@uke.de.
University Medical Center Hamburg-Eppendorf · DEUniversity of Oxford · GBUniversität Hamburg · DE

Funding

Wellcome Trust 101010
6 · The paper itself

Abstract

T cell activation starts with formation of second messengers that release Ca

Indexed as

2-MethoxyestradiolAnimalsCalciumCalcium SignalingCell LineCell NucleusEstrenesGene Expression RegulationHumansJurkat CellsLymphocyte ActivationNFATC Transcription FactorsProtein TransportRatsT-Lymphocytes2-MethoxyestradiolCalciumEstrenesNFATC Transcription FactorsCa(2+) signalingORAI inhibitorStore-operated Ca(2+) entryT cell activation

Identifiers

PMID33581218
PMCPMC8062851
OpenAlexW3127998669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.