Evidence map›Paper›PMID 33581094›Full record

Observational studyEnvironmental research2021

Acute myocardial infarction associated with unconventional natural gas development: A natural experiment.

Alina Denham, Mary D Willis, Daniel P Croft, Linxi Liu, Elaine L Hill

Abstract readObservational Study
In one paragraph

Observational study in Environmental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Impact of oil and gas boom and busts on working-age mortality in the U.S.Environmental epidemiology (Philadelphia, Pa.) · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Sociodemographic and Population Exposure to Upstream Oil and Gas Operations in Canada.International journal of environmental research and public health · 2024
    Article
  6. Article
  7. Article
  8. The human health effects of unconventional oil and gas development (UOGD): A scoping review of epidemiologic studies.Canadian journal of public health = Revue canadienne de sante publique · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
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  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alina DenhamDepartment of Public Health Sciences School of Medicine and Dentistry, University of Rochester 265 Crittenden Blvd, Rochester, NY, 14642, United States.
Mary D WillisSchool of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, United States; Department of Epidemiology, School of Public Health, Boston University, Boston, MA, United States.
Daniel P CroftDepartment of Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, United States.
Linxi LiuDepartment of Public Health Sciences School of Medicine and Dentistry, University of Rochester 265 Crittenden Blvd, Rochester, NY, 14642, United States.
Elaine L HillDepartment of Public Health Sciences School of Medicine and Dentistry, University of Rochester 265 Crittenden Blvd, Rochester, NY, 14642, United States. Electronic address: elaine_hill@urmc.rochester.edu.

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Martha Susiarjo · 1985 to 2026
$42.8M
Oregon Clinical and Translational Research Institute TL1 ProgramTL1TR002371 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALLISON Deborah FRYER, JESSINA C MCGREGOR · 2017 to 2026
$6.2M
The Health Consequences of Shale Gas DevelopmentDP5OD021338 · OD · UNIVERSITY OF ROCHESTER · PI HILL, ELAINE L · 2015 to 2019
$1.9M
Effect of Air Pollution on the Immune Response to Respiratory Viral Infection in AdultsK23ES032459 · NIEHS · UNIVERSITY OF ROCHESTER · PI CROFT, DANIEL PATRICK · 2021 to 2025
$1.2M
Environmental Data Integration to Assess Impacts of Shale Gas Development on Perinatal Health Outcomes and Childhood CancersF31ES029801 · NIEHS · OREGON STATE UNIVERSITY · PI WILLIS, MARY D · 2019 to 2020
$55k
NCATS NIH HHS TL1 TR002371NIEHS NIH HHS F31 ES029801NIEHS NIH HHS K23 ES032459NIEHS NIH HHS P30 ES001247NIH HHS DP5 OD021338
6 · The paper itself

Abstract

backgroundWhereas it is plausible that unconventional natural gas development (UNGD) may adversely affect cardiovascular health, little is currently known. We investigate whether UNGD is associated with acute myocardial infarction (AMI).

methodsIn this observational study leveraging the natural experiment generated by New York's ban on hydraulic fracturing, we analyzed the relationship between age- and sex-specific county-level AMI hospitalization and mortality rates and three UNGD drilling measures. This longitudinal panel analysis compares Pennsylvania and New York counties on the Marcellus Shale observed over 2005-2014 (N = 2840 county-year-quarters).

resultsA hundred cumulative wells is associated with 0.26 more hospitalizations per 10,000 males 45-54y.o. (95% CI 0.07,0.46), 0.40 more hospitalizations per 10,000 males 65-74y.o. (95% CI 0.09,0.71), 0.47 more hospitalizations per 10,000 females 65-74y.o. (95% CI 0.18,0.77) and 1.11 more hospitalizations per 10,000 females 75y.o.+ (95% CI 0.39,1.82), translating into 1.4-2.8% increases. One additional well per square mile is associated with 2.63 more hospitalizations per 10,000 males 45-54y.o. (95% CI 0.67,4.59) and 9.7 hospitalizations per 10,000 females 75y.o.+ (95% CI 1.92,17.42), 25.8% and 24.2% increases, respectively. As for mortality rates, a hundred cumulative wells is associated with an increase of 0.09 deaths per 10,000 males 45-54y.o. (95% CI 0.02,0.16), a 5.3% increase.

conclusionsCumulative UNGD is associated with increased AMI hospitalization rates among middle-aged men, older men and older women as well as with increased AMI mortality among middle-aged men. Our findings lend support for increased awareness about cardiovascular risks of UNGD and scaled-up AMI prevention as well as suggest that bans on hydraulic fracturing can be protective for public health.

Indexed as

Myocardial InfarctionNatural GasAgedEnvironmental ExposureFemaleHospitalizationHumansMaleMiddle AgedNew YorkPennsylvaniaNatural GasCardiovascular healthEnvironmental healthFrackingIndustrial emissionsUnconventional natural gas development

Identifiers

PMID33581094
PMCPMC7987810

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.