Evidence map›Paper›PMID 33581073›Full record

ArticleCurrent biology : CB2021

Hippocampal place cells encode global location but not connectivity in a complex space.

Éléonore Duvelle, Roddy M Grieves, Anyi Liu, Selim Jedidi-Ayoub, Joanna Holeniewska, Adam Harris, Nils Nyberg, Francesco Donnarumma, Julie M Lefort, Kate J Jeffery and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Éléonore DuvelleDepartment of Experimental Psychology, Institute of Behavioural Neuroscience, University College London, London, UK; Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA. Electronic address: e.duvelle@ucl.ac.uk.
Roddy M GrievesDepartment of Experimental Psychology, Institute of Behavioural Neuroscience, University College London, London, UK; Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA.
Anyi LiuDepartment of Experimental Psychology, Institute of Behavioural Neuroscience, University College London, London, UK.
Selim Jedidi-AyoubDepartment of Experimental Psychology, Institute of Behavioural Neuroscience, University College London, London, UK.
Joanna HoleniewskaDepartment of Experimental Psychology, Institute of Behavioural Neuroscience, University College London, London, UK.
Adam HarrisDepartment of Experimental Psychology, University of Oxford, OX2 6BW Oxford, UK.
Nils NybergDepartment of Experimental Psychology, Institute of Behavioural Neuroscience, University College London, London, UK.
Francesco DonnarummaInstitute of Cognitive Sciences and Technologies, National Research Council, via S. Martino d. Battaglia 44, 00185 Rome, Italy.
Julie M LefortUniversity College London, Department of Cell and Developmental Biology, London, UK.
Kate J JefferyDepartment of Experimental Psychology, Institute of Behavioural Neuroscience, University College London, London, UK.
Christopher SummerfieldDepartment of Experimental Psychology, University of Oxford, OX2 6BW Oxford, UK.
Giovanni PezzuloInstitute of Cognitive Sciences and Technologies, National Research Council, via S. Martino d. Battaglia 44, 00185 Rome, Italy.
Hugo J SpiersDepartment of Experimental Psychology, Institute of Behavioural Neuroscience, University College London, London, UK. Electronic address: h.spiers@ucl.ac.uk.
University College London · GBDartmouth College · USNational Research Council · ITUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flexible navigation relies on a cognitive map of space, thought to be implemented by hippocampal place cells: neurons that exhibit location-specific firing. In connected environments, optimal navigation requires keeping track of one's location and of the available connections between subspaces. We examined whether the dorsal CA1 place cells of rats encode environmental connectivity in four geometrically identical boxes arranged in a square. Rats moved between boxes by pushing saloon-type doors that could be locked in one or both directions. Although rats demonstrated knowledge of environmental connectivity, their place cells did not respond to connectivity changes, nor did they represent doorways differently from other locations. Place cells coded location in a global reference frame, with a different map for each box and minimal repetitive fields despite the repetitive geometry. These results suggest that CA1 place cells provide a spatial map that does not explicitly include connectivity.

Indexed as

Place CellsSpace PerceptionAction PotentialsAnimalsHippocampusRatsdetourfour-room mazehippocampusnavigationplace cellsplace field repetitionratspatial connectivitytopologytransitions

Identifiers

PMID33581073
PMCPMC7988036
OpenAlexW3131925626

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.