Observational studyClinical and translational science2021
Metabolomics analysis of the serum from children with urolithiasis using UPLC-MS.
Observational study in Clinical and translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Serum and urine metabolomic profiling in Miniature Schnauzer dogs with and without calcium oxalate urolithiasis.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Article
- Metabolomic and lipidomic profiling of plasma in kidney stone patients: identification of potential biomarkers and therapeutic targets.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Identification of the relationship between 1400 blood metabolites and urolithiasis: A bidirectional Mendelian randomization study.Medicine · 2025Article
- Characterization of gut microbiome dysbiosis in calcium oxalate stone patients with comorbid metabolic syndrome.Frontiers in microbiology · 2025Article
- Integration of bile proteomics and metabolomics analyses reveals novel insights into different types of gallstones in a high-altitude area.BMC gastroenterology · 2024Article
- Advances in metabolomics profiling of pediatric kidney diseases: A review.Biomolecules & biomedicine · 2024Review
- Mendelian randomization study of urolithiasis: exploration of risk factors using human blood metabolites.BMC urology · 2024Article
- Serum metabolomics study reveals a distinct metabolic diagnostic model for renal calculi.Heliyon · 2024Article
- Management of Pediatric Urolithiasis in an Italian Tertiary Referral Center: A Retrospective Analysis.Medicina (Kaunas, Lithuania) · 2023Article
- New Insights from Metabolomics in Pediatric Renal Diseases.Children (Basel, Switzerland) · 2022Review
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
Pediatric urolithiasis is a common urologic disease with high morbidity and recurrence rates. Recent studies have shown that metabolic dysfunction plays a vital role in the pathogenesis of urolithiasis, especially in children, but the specific mechanism is still unclear. Metabolomics is an ideal technology for exploring the mechanism of metabolic disorders in urolithiasis. In the present study, a serum metabolomics based on ultra-performance liquid chromatography mass spectrometry was performed. A total of 50 children subjects were recruited for the study, including 30 patients with kidney stones and 20 normal controls (NCs). Principal component analysis and orthogonal partial least-squares determinant analysis were carried, and 40 metabolites were found to be significantly altered in patients with kidney stones, mainly involving retinol metabolism, steroid hormone biosynthesis, and porphyrin and chlorophyll metabolism. The kidney stone group appeared to have a lower serum level of bilirubin, but a relative higher level of retinal, all-transretinoic acid, progesterone, and prostaglandin E2 compared with those of the NC group. All the findings suggest that patients with urolithiasis have several metabolic characteristics, which are related to stone formation or compensation. These metabolites and pathways are very likely associated with development of kidney stones and should be considered as potential novel targets for treatment and prevention.
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