Evidence map›Paper›PMID 33580972›Full record

ReviewAmerican journal of hematology2021

Intravenous ferric derisomaltose for the treatment of iron deficiency anemia.

Michael Auerbach, David Henry, Thomas G DeLoughery

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in American journal of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06830941 (Efficacy and Safety of Iron Isomaltoside in the Treatment of Peritoneal Dialysis Patients with Renal Related Anemia), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06830941 phase4not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy and Safety of Iron Isomaltoside in the Treatment of Peritoneal Dialysis Patients with Renal Related Anemia: a Randomized Controlled Trial

TypeinterventionalSponsorXie Jingyuan, MDRan2025 to 2027Enrolled124ConditionsRenal Anemia, Peritoneal Dialysis (PD)ArmsIron isomaltoside, Ferrous succinate
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Expert opinion on the management of anemia in prostate cancer patients receiving PARP inhibitors.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. IV iron formulations and use in adults.Hematology. American Society of Hematology. Education Program · 2023
    Article
  15. SucrosomialPharmaceuticals (Basel, Switzerland) · 2023
    Review
  16. Review
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Michael AuerbachDepartment of Medicine, Georgetown University School of Medicine, Washington, District of Columbia.ORCID 0000-0003-0707-8647
David HenryDepartment of Medicine, Division of Hematology and Oncology, Pennsylvania Hospital, Philadelphia, Pennsylvania.
Thomas G DeLougheryDepartment of Hematology and Medical Oncology, Knight Cancer Center, Oregon Health & Sciences University, Oregon, Portland.ORCID 0000-0002-5790-4700
Georgetown University · USOregon Health & Science University · USPennsylvania Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intravenous (IV) iron is the therapy of choice when oral iron is ineffective or poorly tolerated, yet use has been limited by fears of hypersensitivity reactions (HSRs). Newer formulations that bind iron more tightly and release it more slowly have made the risk of serious or severe HSRs very low. One such formulation, ferric derisomaltose, has been approved in the United States for delivery of 1000 mg iron in a single IV infusion. Ferric derisomaltose rapidly repletes iron parameters with low rates of serious or severe HSRs. Single-infusion iron repletion offers convenience, eliminates adherence concerns, and reduces healthcare resource utilization.

Indexed as

Anemia, Iron-DeficiencyBiomarkersCardiovascular DiseasesDiagnosis, DifferentialDisaccharidesDrug CostsDrug HypersensitivityFatigueFemaleFerric CompoundsFlushingForecastingHemoglobinsHumansHypophosphatemiaInfusions, IntravenousBiomarkersDisaccharidesFerric Compoundsferric derisomaltoseHemoglobinsiron isomaltoside 1000

Identifiers

PMID33580972
PMCPMC8248147
OpenAlexW3129734173

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.