Evidence map›Paper›PMID 33580909›Full record

ArticleMagnetic resonance in medicine2021

Magnetization-prepared GRASP MRI for rapid 3D T1 mapping and fat/water-separated T1 mapping.

Li Feng, Fang Liu, Georgios Soultanidis, Chenyu Liu, Thomas Benkert, Kai Tobias Block, Zahi A Fayad, Yang Yang

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 54 citations in OpenAlex.

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  8. Free-breathing phase-sensitive inversion recovery TMagnetic resonance in medicine · 2026
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  11. Accelerated Abdominal MRI: A Review of Current Methods and Applications.Journal of magnetic resonance imaging : JMRI · 2025
    Review
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  15. MRI of GlycoNOE in the human liver using GraspNOE-Dixon.Magnetic resonance in medicine · 2025
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  19. DeepEMC-TMagnetic resonance in medicine · 2024
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  20. Free-breathing, fat-corrected TMagnetic resonance in medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Li FengBiomedical Engineering and Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-8692-7645
Fang LiuDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8032-6681
Georgios SoultanidisBiomedical Engineering and Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Chenyu LiuBiomedical Engineering and Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Thomas BenkertMR Application Development, Siemens Healthcare GmbH, Erlangen, Germany.
Kai Tobias BlockMR Application Development, Siemens Healthcare GmbH, Erlangen, Germany.
Zahi A FayadBiomedical Engineering and Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yang YangBiomedical Engineering and Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-2841-4243
Icahn School of Medicine at Mount Sinai · USAdvanced Imaging Research (United States) · USHarvard University · USSiemens Healthineers (Germany) · DE

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Hersh Chandarana · 2014 to 2026
$19.3M
Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Kira Grogg · 2017 to 2026
$14.8M
NIBIB NIH HHS P41 EB017183NIBIB NIH HHS P41 EB022544
6 · The paper itself

Abstract

purposeThis study aimed to (i) develop Magnetization-Prepared Golden-angle RAdial Sparse Parallel (MP-GRASP) MRI using a stack-of-stars trajectory for rapid free-breathing T1 mapping and (ii) extend MP-GRASP to multi-echo acquisition (MP-Dixon-GRASP) for fat/water-separated (water-specific) T1 mapping.

methodsAn adiabatic non-selective 180° inversion-recovery pulse was added to a gradient-echo-based golden-angle stack-of-stars sequence for magnetization-prepared 3D single-echo or 3D multi-echo acquisition. In combination with subspace-based GRASP-Pro reconstruction, the sequence allows for standard T1 mapping (MP-GRASP) or fat/water-separated T1 mapping (MP-Dixon-GRASP), respectively. The accuracy of T1 mapping using MP-GRASP was evaluated in a phantom and volunteers (brain and liver) against clinically accepted reference methods. The repeatability of T1 estimation was also assessed in the phantom and volunteers. The performance of MP-Dixon-GRASP for water-specific T1 mapping was evaluated in a fat/water phantom and volunteers (brain and liver).

resultsROI-based mean T1 values are correlated between the references and MP-GRASP in the phantom (R

conclusionThis work demonstrated the initial performance of MP-GRASP and MP-Dixon-GRASP MRI for rapid 3D T1 mapping and 3D fat/water-separated T1 mapping in the brain (without motion) and in the liver (during free breathing). With fat/water-separated T1 estimation, MP-Dixon-GRASP could be potentially useful for imaging patients with fatty-liver diseases.

Indexed as

Magnetic Resonance ImagingWaterHumansImaging, Three-DimensionalLiverPhantoms, ImagingRespirationWaterfat/water separationfree-breathinggolden-angle radialMP-Dixon-GRASPMP-GRASPT1 mapping

Identifiers

PMID33580909
PMCPMC8197608
OpenAlexW3126904093

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.