ReviewProbiotics and antimicrobial proteins2021
Can Probiotics Emerge as Effective Therapeutic Agents in Apical Periodontitis? A Review.
Review in Probiotics and antimicrobial proteins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- A preliminary antimicrobial investigation of lactobacillus bulgaricus probiotic supernatants as an intracanal medication against mature E. faecalis biofilm in an ex-vivo dentin blocks model.Clinical oral investigations · 2026Article
- Effects of live and heat-killed Bifidobacterium lactis in rats with induced periodontitis.Journal of applied oral science : revista FOB · 2026Article
- Postbiotics Derived fromNutrients · 2025Article
- Antibacterial efficacy of ultrasonically activated probiotic endodontic irrigant against Enterococcus faecalis biofilm: an in-vitro study.BMC oral health · 2025Article
- Anti-microbial effect of probiotic versus silver nanoparticle irrigant.Bioinformation · 2025Article
- Optimization of a novel dental self-healing resin composite by bacteria-induced biomineralization.Frontiers in bioengineering and biotechnology · 2025Article
- Acupuncture as a Complementary Therapy in Conservative and Endodontic Procedures: A Narrative Review.Cureus · 2024Review
- Strategies and mechanisms targetingFrontiers in cellular and infection microbiology · 2024Review
- Bifidobacterium animalis subsp. lactis HN019 has antimicrobial activity against endodontic pathogens in vitro.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Antibacterial effectiveness of multi-strain probiotics supernatants intracanal medication on Enterococcus faecalis biofilm in a tooth model.BMC oral health · 2023Article
- Diagnostic performance of cone-beam computed tomography for apical periodontitis: a systematic review and meta-analysis.Polish journal of radiology · 2023Review
- Evaluation of the antibacterial activity of Lactobacilli probiotics supernatants against Enterococcus faecalis (in-vitro study).BMC oral health · 2022Article
- The Products of Probiotic Bacteria Effectively Treat PersistentPharmaceutics · 2022Article
- Mechanisms of bone remodeling and therapeutic strategies in chronic apical periodontitis.Frontiers in cellular and infection microbiology · 2022Review
- How Adding Chlorhexidine or Metallic Nanoparticles Affects the Antimicrobial Performance of Calcium Hydroxide Paste as an Intracanal Medication: An In Vitro Study.Antibiotics (Basel, Switzerland) · 2021Article
- Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis.Frontiers in cellular and infection microbiology · 2021Review
- Symbiotic probiotic communities with multiple targets successfully combat obesity in high-fat-diet-fed mice.Gut microbesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apical periodontitis (AP) is a biofilm-associated disease initiated by the invasion of dental pulp by microorganisms from the oral cavity. Eradication of intracanal microbial infection is an important goal of endodontic treatment, and this is typically accomplished by mechanical instrumentation and application of sodium hypochlorite and chlorhexidine. However, these agents are tissue-irritating at higher concentrations and cytotoxic. Certain probiotics have been found effective in controlling marginal periodontitis, as evidenced by reduction of pathogenic bacterial loads, gains in clinical attachment levels, and reduced bleeding on probing. In vitro studies have shown inhibitory activity of some probiotics against endodontic pathogens. Similarly, in vivo studies in rats have demonstrated a positive immuno-modulatory role of probiotics in AP, as manifested by decreased levels of proinflammatory markers and increased levels of anti-inflammatory markers. A role for probiotics in effecting a reduction of bone resorption has also been reported. This review provides an outline of current research into the probiotic management of AP, with a focus on understanding the mechanisms of their direct antagonistic activity against target pathogens and of their beneficial modulation of the immune system.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.